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dc.contributor.authorÇakmakoğlu, Bedia
dc.contributor.authorErtuğrul, Barış
dc.contributor.authorTacal Aslan, Beste
dc.contributor.authorİplik, Elif Sinem
dc.date.accessioned2021-03-02T17:06:23Z
dc.date.available2021-03-02T17:06:23Z
dc.date.issued2020
dc.identifier.citationTacal Aslan B., Ertuğrul B., İplik E. S. , Çakmakoğlu B., "Apoptotic effects of acacetin in human colon cancer HT‑29 and HCT 116 cells", Journal Of Cancer Research And Therapeutics, cilt.1, ss.1-4, 2020
dc.identifier.issn0973-1482
dc.identifier.othervv_1032021
dc.identifier.otherav_dedd4d41-3e44-4d82-ac59-2335f2f15615
dc.identifier.urihttp://hdl.handle.net/20.500.12627/3540
dc.identifier.urihttps://doi.org/10.4103/jcrt.jcrt_1097_19
dc.identifier.urihttps://avesis.istanbul.edu.tr/api/publication/dedd4d41-3e44-4d82-ac59-2335f2f15615/file
dc.description.abstractAim: Acacetin is a natural flavone compound, which is found in several plants as Robinia pseudoacacia and is demonstrated to haveanticancerogenic activities in many types of cancer (e.g., human nonsmall cell lung cancer, and prostate). Colorectal carcinoma (CRC)is one of the serious health problems and is a complex disease. We intended to find a more effective new candidate for the treatmentof colon cancer, and hence, we designed this study to investigate the effects of acacetin on CRC (HT‑29, HCT 116) in vitro.Methods: The study was carried out with the methods that determine for apoptosis (WST‑1, Caspase 3/BCA, Annexin V).Results: Acacetin showed antitumor and apoptosis‑inducing effects in the CRC cell lines.Conclusions: Acacetin was effective on CRC cell lines, besides no lethal effect on healthy lung cells (MRC‑5).
dc.language.isoeng
dc.subjectKlinik Tıp (MED)
dc.subjectÇOK DİSİPLİNLİ BİLİMLER
dc.subjectDoğa Bilimleri Genel
dc.subjectTemel Bilimler (SCI)
dc.subjectTemel Bilimler
dc.subjectSağlık Bilimleri
dc.titleApoptotic effects of acacetin in human colon cancer HT‑29 and HCT 116 cells
dc.typeMakale
dc.relation.journalJournal Of Cancer Research And Therapeutics
dc.contributor.departmentMarmara Üniversitesi , Diş Hekimliği Fakültesi , Diş Hekimliği Temel Tıp Bilimleri Bölümü
dc.identifier.volume1
dc.identifier.issue1
dc.identifier.startpage1
dc.identifier.endpage4
dc.contributor.firstauthorID2207185


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