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dc.contributor.authorEraksoy, Mefküre
dc.contributor.authorBaykal, Betül
dc.contributor.authorSaruhan Direskeneli, Güher
dc.date.accessioned2021-03-03T16:30:46Z
dc.date.available2021-03-03T16:30:46Z
dc.date.issued1997
dc.identifier.citationEraksoy M., Saruhan Direskeneli G., Baykal B., "HLA-DR and -DQ Associations with Multiple Sclerosis in Turkey", Human Immunology, cilt.55, sa.1, ss.59-65, 1997
dc.identifier.issn0198-8859
dc.identifier.othervv_1032021
dc.identifier.otherav_44a4a829-9119-42a3-925e-87b4d07fb5b0
dc.identifier.urihttp://hdl.handle.net/20.500.12627/49814
dc.identifier.urihttps://avesis.istanbul.edu.tr/api/publication/44a4a829-9119-42a3-925e-87b4d07fb5b0/file
dc.identifier.urihttps://doi.org/10.1016/s0198-8859(97)
dc.description.abstractABSTRACT: The DRB, DQA, and DQB subregions ofthe major histocompatibility complex (MHC) were investigatedby polymerase chain reaction and sequence-specificoligonucleotide probe hybridization (PCR/SSO) in103 multiple sclerosis (MS) patients and 101 healthycontrols from Turkey. Significant differences were detectedbetween MS and control populations in the frequencies ofDRB1*1501 [29 vs. 14, p 5 0.02, odds ratio (OR) 5 2.4],DRB1*04 (35 vs. 18, p 5 0.01, OR 5 2.3), DQB1*0302(30 vs. 15, p 5 0.02, OR 5 2.3), DQB1*0602 (27 vs. 10,p 5 0.005, OR 5 3.2), DQB1*0501 (10 vs. 24, p 5 0.01,OR 5 0.3), DQA1*0101 (16 vs. 31, p 5 0.02, OR 50.4), and DQA1*0103 (7 vs. 19, p 5 0.02, OR 5 0.3).These results confirm the proposed positive association ofthe Dw2 (DRB1*1501 DQA1*0102 DQB1*0602) haplotypewith MS in Caucasians in our Turkish population(25 vs. 8, p 5 0.003, OR 5 3.7). Furthermore, the“putative” haplotype supposed to be more frequent in theMS population of Mediterranean countries, namelyDRB1*04 DQA1*03 DQB1*0302, is also associatedwith MS in Turkey (29 vs. 12, p 5 0.006, OR 5 2.9).The presence of two different haplotypic associations inMS emphasizes the complexity of the genetic susceptibilityto MS in different populations.
dc.language.isoeng
dc.subjectPathophysiology
dc.subjectInternal Medicine
dc.subjectAssessment and Diagnosis
dc.subjectMedicine (miscellaneous)
dc.subjectGeneral Medicine
dc.subjectHealth Sciences
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectTIP, GENEL & İÇECEK
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectDahili Tıp Bilimleri
dc.subjectFamily Practice
dc.subjectFundamentals and Skills
dc.subjectGeneral Health Professions
dc.titleHLA-DR and -DQ Associations with Multiple Sclerosis in Turkey
dc.typeMakale
dc.relation.journalHuman Immunology
dc.contributor.departmentİstanbul Üniversitesi , İstanbul Tıp Fakültesi , Dahili Tıp Bilimleri Bölümü
dc.identifier.volume55
dc.identifier.issue1
dc.identifier.startpage59
dc.identifier.endpage65
dc.contributor.firstauthorID2522234


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