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dc.contributor.authorDamar Çelik, Damla
dc.contributor.authorÖzbek Çelik, Berna
dc.contributor.authorNørskov-Lauritsen, Niels
dc.date.accessioned2021-03-02T18:34:10Z
dc.date.available2021-03-02T18:34:10Z
dc.date.issued2020
dc.identifier.citationDamar Çelik D., Özbek Çelik B., Nørskov-Lauritsen ., " Post-antibiotic Effect of Various Antibiotics against Achromobacter xylosoxidans Strains Isolated from Patients with Cystic Fibrosis", J Clin Exp Invest, cilt.11, sa.4, ss.1-5, 2020
dc.identifier.othervv_1032021
dc.identifier.otherav_5c579336-7c95-4076-8c7c-64db59604473
dc.identifier.urihttp://hdl.handle.net/20.500.12627/5178
dc.identifier.urihttps://avesis.istanbul.edu.tr/api/publication/5c579336-7c95-4076-8c7c-64db59604473/file
dc.identifier.urihttps://doi.org/10.5799/jcei/8294
dc.description.abstractObjectives:Achromobacter xylosoxidansis an emerging pathogen in cystic fibrosis (CF) disease, although relatively limited is known about its clinical impact and optimal management. Pharmacodynamics such as post-antibiotic effect (PAE) are increasingly being applied to the design of antibiotic dosing regimens. In the present study, meropenem, doripenem, colistin, levofloxacin, tigecycline, tobramycin, and chloramphenicol were tested for their PAE.Materials and Methods:The in vitro activities of meropenem, doripenem, colistin, levofloxacin, tigecycline, tobramycin, and chloramphenicol were determined by the microbroth dilution technique. To determine the PAEs,A. xylosoxidansstrains in the logarithmic phase of growth were exposed for 1 h to antibiotics. Recovery periods of test cultures were evaluated using viable counting after centrifugation.Results:The mean values ofin vitro PAEs at 1xMIC and 4xMICconcentrations were 3.21 ± 0.66 and 3.58 ± 0.68 hoursfor colistin, 1.54 ± 0.46 and 2.27 ± 0.41 hours for levofloxacin, 2.34 ± 0.48 and 3.47 ± 0.64 hours for tobramycin, 1.72 ± 0.47 and 2.24 ± 0.41 hours for tigecycline 1.91 ± 0.14 and 2.13 ± 0.13 hours for chloramphenicol, respectively. The carbapenem antibiotics exhibited weak PAEs, as expected.Conclusions:This study’s findings could have important implications for the timing of doses during antimicrobial therapy with tested antibiotics.
dc.language.isoeng
dc.subjectKlinik Tıp (MED)
dc.subjectSağlık Bilimleri
dc.titlePost-antibiotic Effect of Various Antibiotics against Achromobacter xylosoxidans Strains Isolated from Patients with Cystic Fibrosis
dc.typeMakale
dc.relation.journalJ Clin Exp Invest
dc.contributor.departmentMarmara Üniversitesi , Eczacılık Fakültesi , Temel Eczacılık Bilimleri Bölümü
dc.identifier.volume11
dc.identifier.issue4
dc.identifier.startpage1
dc.identifier.endpage5
dc.contributor.firstauthorID839957


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