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dc.contributor.authorYıldız, Yaşar Kemal
dc.contributor.authorKaragöz, Ali
dc.contributor.authorGören, Ahmet Ceyhan
dc.contributor.authorAslan, İrfan
dc.contributor.authorAydoğmuş, Zeynep
dc.contributor.authorKılıç, Turgut
dc.contributor.authorTopçu, Gülaçtı
dc.date.accessioned2021-03-04T11:49:22Z
dc.date.available2021-03-04T11:49:22Z
dc.date.issued2020
dc.identifier.citationKılıç T., Topçu G., Gören A. C. , Aydoğmuş Z., Karagöz A., Yıldız Y. K. , Aslan İ., "Ent-kaurene Diterpenoids from Sideritis lycia with Antiviral and Cytotoxic Activities", RECORDS OF NATURAL PRODUCTS, cilt.14, sa.4, ss.256-268, 2020
dc.identifier.issn1307-6167
dc.identifier.othervv_1032021
dc.identifier.otherav_74426700-e55a-400a-ac60-f91230230263
dc.identifier.urihttp://hdl.handle.net/20.500.12627/79909
dc.identifier.urihttps://avesis.istanbul.edu.tr/api/publication/74426700-e55a-400a-ac60-f91230230263/file
dc.identifier.urihttps://doi.org/10.25135/rnp.163.19.08.1373
dc.description.abstractThe genus Sideritis (Lamiaceae) is represented by 45 species (54 taxa) in Anatolia with high endemism ratio (74%), and Turkey is one of the gene centers of the genus along with Spain. Acetone extract of the aerial parts of Sideritis lycia afforded eight known ent-kaurene diterpenoids, structures of which have been identified as linearol, isolinearol, isosidol, sidol, siderol, sideridiol, 7-epi-candicandiol and foliol through 1H NMR, 13 C NMR and mass spectroscopic analyses. Cytotoxic and antiviral activities of the acetone extract, linearol, sidol and isosidol were investigated together with insecticidal activity of species. The antiviral index of linearol, isosidol and acetone extract of S. lycia were determined as 2.31, 2.01 and 2.58, respectively, except sidol. 7-Epi-candicandiol was found to be the most active diterpene against a series of cancer cell lines with ED50 values; KB (13.3 mu g/mL), COL-2 (11.8 mu g/mL), LU1 (17.9 mu g/mL), LNCaP (14.9 mu g/mL) and A2780 (9.0 mu g/mL). Activity results of this study indicated that ent-kaurane diterpenes have potential to be considered as antiviral and cytotoxic lead compounds.
dc.language.isoeng
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectSağlık Bilimleri
dc.subjectEczacılık
dc.subjectTemel Eczacılık Bilimleri
dc.subjectTarımsal Bilimler
dc.subjectZiraat
dc.subjectBitki Koruma
dc.subjectFitopatoloji
dc.subjectYaşam Bilimleri
dc.subjectBiyokimya
dc.subjectDiğer
dc.subjectTemel Bilimler
dc.subjectFARMAKOLOJİ VE ECZACILIK
dc.subjectFarmakoloji ve Toksikoloji
dc.subjectKİMYA, TIP
dc.subjectTemel Bilimler (SCI)
dc.subjectKimya
dc.subjectKİMYA, UYGULAMALI
dc.subjectTarım ve Çevre Bilimleri (AGE)
dc.subjectBitki ve Hayvan Bilimleri
dc.subjectBİTKİ BİLİMLERİ
dc.titleEnt-kaurene Diterpenoids from Sideritis lycia with Antiviral and Cytotoxic Activities
dc.typeMakale
dc.relation.journalRECORDS OF NATURAL PRODUCTS
dc.contributor.departmentBalıkesir Üniversitesi , ,
dc.identifier.volume14
dc.identifier.issue4
dc.identifier.startpage256
dc.identifier.endpage268
dc.contributor.firstauthorID717241


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