Show simple item record

dc.contributor.authorHancer, Veysel Sabri
dc.contributor.authorTopal-Sarikaya, Aysegul
dc.contributor.authorKucukkaya, Reyhan Diz
dc.date.accessioned2021-03-05T07:45:42Z
dc.date.available2021-03-05T07:45:42Z
dc.date.issued2011
dc.identifier.citationHancer V. S. , Kucukkaya R. D. , Topal-Sarikaya A., "ADAMTS-13 gene expression in antiphospholipid syndrome", TURKISH JOURNAL OF HEMATOLOGY, cilt.28, ss.213-218, 2011
dc.identifier.issn1300-7777
dc.identifier.otherav_957f8610-5d05-498a-92bb-b0b77f527e08
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/100657
dc.identifier.urihttps://doi.org/10.5152/tjh.2011.56
dc.description.abstractAntiphospholipid syndrome (APS) is an autoimmune disorder characterized by recurrent thrombosis and fetal mortality. Thrombotic microangiopathy (TMA) is an important histological finding in catastrophic APS (CAPS) and in APS patients with nephropathy. Analysis of familial thrombotic thrombocytopenic purpura patients showed that there are mutations in the ADAMTS-13 gene that lead to functional defects in the ADAMTS-13 enzyme. The aim of this study was to investigate the prevalence of the aforementioned mutations in APS, as well as to evaluate the level and activity of the ADAMTS-13 enzyme in patients with APS. C365del, Q449stop codon, P475S, and C508Y mutations were analyzed in APS patients. Transcriptions were analyzed using real-time PCR, and the level and activity of ADAMTS-13 were analyzed via fluorogenic assay. None of the mutations tested were present in the patient or control groups. The level of ADAMTS-13 mRNA in the patient group was 50% lower than that in the control group. Although a significant difference in ADAMTS-13 activity was not observed between the patient and control groups, a significant association was observed with the level of ADAMTS-13 (p<0.0001). The level and activity of ADAMTS-13 were not associated with thrombotic complications, thrombocytopenia, or pregnancy complications in the patients with APS. (Turk J Hematol 2011; 28: 213-8)
dc.language.isoeng
dc.subjectSağlık Bilimleri
dc.subjectHematoloji
dc.subjectDahili Tıp Bilimleri
dc.subjectİç Hastalıkları
dc.subjectTıp
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectHEMATOLOJİ
dc.titleADAMTS-13 gene expression in antiphospholipid syndrome
dc.typeMakale
dc.relation.journalTURKISH JOURNAL OF HEMATOLOGY
dc.contributor.departmentİstanbul Üniversitesi , ,
dc.identifier.volume28
dc.identifier.issue3
dc.identifier.startpage213
dc.identifier.endpage218
dc.contributor.firstauthorID201617


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record