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Cytotoxic Sesterterpenoids from Bornean Sponge Spongia sp

dc.contributor.authorVairappan, Charles S.
dc.contributor.authorKamada, Takashi
dc.contributor.authorPhan, Chin-Soon
dc.contributor.authorHamada, Toshiyuki
dc.date.accessioned2021-03-05T08:23:51Z
dc.date.available2021-03-05T08:23:51Z
dc.date.issued2018
dc.identifier.citationPhan C., Kamada T., Hamada T., Vairappan C. S. , "Cytotoxic Sesterterpenoids from Bornean Sponge Spongia sp", RECORDS OF NATURAL PRODUCTS, cilt.12, ss.643-647, 2018
dc.identifier.issn1307-6167
dc.identifier.otherav_98a69e67-0c31-4a2a-a33e-53c3cc482aeb
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/102705
dc.identifier.urihttps://doi.org/10.25135/rnp.69.18.01.209
dc.description.abstractFour scalarane sesterterpenoids, scalarolide acetate (1), scalarolide (2), 12-O-deacetyl-12-epi-19-O-methylscalarin (3) and methyl 18-hydroxy-19-norscalar-16-en-20-carboxylate (4) were isolated from the Bornean sponge Spongia sp. The distinction between 12 alpha-OAc and 12 beta-OAc, and 19-olide and 20-olide in sesterterpenes were revealed as well as previously not assigned relative configuration at 18-OH of 4 is reported herein for the first time. In addition, compounds 1-3 showed strong cytotoxic activities against adult T-cell leukemia (ATL), SIT cells. This is the first record of scalarane sesterterpenes from the Bornean sponge.
dc.language.isoeng
dc.subjectFarmakoloji ve Toksikoloji
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectSağlık Bilimleri
dc.subjectEczacılık
dc.subjectTemel Eczacılık Bilimleri
dc.subjectTarımsal Bilimler
dc.subjectZiraat
dc.subjectBitki Koruma
dc.subjectFitopatoloji
dc.subjectYaşam Bilimleri
dc.subjectBiyokimya
dc.subjectDiğer
dc.subjectTemel Bilimler
dc.subjectKİMYA, UYGULAMALI
dc.subjectKİMYA, TIP
dc.subjectFARMAKOLOJİ VE ECZACILIK
dc.subjectTarım ve Çevre Bilimleri (AGE)
dc.subjectBitki ve Hayvan Bilimleri
dc.subjectBİTKİ BİLİMLERİ
dc.subjectKimya
dc.subjectTemel Bilimler (SCI)
dc.titleCytotoxic Sesterterpenoids from Bornean Sponge Spongia sp
dc.typeMakale
dc.relation.journalRECORDS OF NATURAL PRODUCTS
dc.contributor.departmentKagoshima University , ,
dc.identifier.volume12
dc.identifier.issue6
dc.identifier.startpage643
dc.identifier.endpage647
dc.contributor.firstauthorID618044


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