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Discovery of novel isatin-based sulfonamides with potent and selective inhibition of the tumor-associated carbonic anhydrase isoforms IX and XII

dc.contributor.authorSupuran, Claudiu T.
dc.contributor.authorGuzel-Akdemir, Ozlen
dc.contributor.authorKarali, Nilgun
dc.contributor.authorAKDEMİR, ATİLLA
dc.date.accessioned2021-03-05T08:33:49Z
dc.date.available2021-03-05T08:33:49Z
dc.date.issued2015
dc.identifier.citationGuzel-Akdemir O., AKDEMİR A., Karali N., Supuran C. T. , "Discovery of novel isatin-based sulfonamides with potent and selective inhibition of the tumor-associated carbonic anhydrase isoforms IX and XII", ORGANIC & BIOMOLECULAR CHEMISTRY, cilt.13, ss.6493-6499, 2015
dc.identifier.issn1477-0520
dc.identifier.othervv_1032021
dc.identifier.otherav_99856404-153c-48ab-9095-e7986dcf42bb
dc.identifier.urihttp://hdl.handle.net/20.500.12627/103249
dc.identifier.urihttps://doi.org/10.1039/c5ob00688k
dc.description.abstractA series of 2/3/4-[(2-oxo-1,2-dihydro-3H-indol-3-ylidene)amino]benzenesulfonamides, obtained from substituted isatins and 2-, 3- or 4-aminobenzenesulfonamide, showed low nanomolar inhibitory activity against the tumor associated carbonic anhydrase (CA, EC 4.2.1.1) isoforms IX and XII - recently validated antitumor drug targets, being much less effective as inhibitors of the off-target cytosolic isoforms CA I and II.
dc.language.isoeng
dc.subjectTemel Bilimler (SCI)
dc.subjectBiyoinorganik Kimya
dc.subjectTemel Bilimler
dc.subjectBiyokimya
dc.subjectKimya
dc.subjectKİMYA, ORGANİK
dc.titleDiscovery of novel isatin-based sulfonamides with potent and selective inhibition of the tumor-associated carbonic anhydrase isoforms IX and XII
dc.typeMakale
dc.relation.journalORGANIC & BIOMOLECULAR CHEMISTRY
dc.contributor.departmentUniversity of Florence , ,
dc.identifier.volume13
dc.identifier.issue23
dc.identifier.startpage6493
dc.identifier.endpage6499
dc.contributor.firstauthorID47687


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