dc.contributor.author | Supuran, Claudiu T. | |
dc.contributor.author | Guzel-Akdemir, Ozlen | |
dc.contributor.author | Karali, Nilgun | |
dc.contributor.author | AKDEMİR, ATİLLA | |
dc.date.accessioned | 2021-03-05T08:33:49Z | |
dc.date.available | 2021-03-05T08:33:49Z | |
dc.date.issued | 2015 | |
dc.identifier.citation | Guzel-Akdemir O., AKDEMİR A., Karali N., Supuran C. T. , "Discovery of novel isatin-based sulfonamides with potent and selective inhibition of the tumor-associated carbonic anhydrase isoforms IX and XII", ORGANIC & BIOMOLECULAR CHEMISTRY, cilt.13, ss.6493-6499, 2015 | |
dc.identifier.issn | 1477-0520 | |
dc.identifier.other | vv_1032021 | |
dc.identifier.other | av_99856404-153c-48ab-9095-e7986dcf42bb | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/103249 | |
dc.identifier.uri | https://doi.org/10.1039/c5ob00688k | |
dc.description.abstract | A series of 2/3/4-[(2-oxo-1,2-dihydro-3H-indol-3-ylidene)amino]benzenesulfonamides, obtained from substituted isatins and 2-, 3- or 4-aminobenzenesulfonamide, showed low nanomolar inhibitory activity against the tumor associated carbonic anhydrase (CA, EC 4.2.1.1) isoforms IX and XII - recently validated antitumor drug targets, being much less effective as inhibitors of the off-target cytosolic isoforms CA I and II. | |
dc.language.iso | eng | |
dc.subject | Temel Bilimler (SCI) | |
dc.subject | Biyoinorganik Kimya | |
dc.subject | Temel Bilimler | |
dc.subject | Biyokimya | |
dc.subject | Kimya | |
dc.subject | KİMYA, ORGANİK | |
dc.title | Discovery of novel isatin-based sulfonamides with potent and selective inhibition of the tumor-associated carbonic anhydrase isoforms IX and XII | |
dc.type | Makale | |
dc.relation.journal | ORGANIC & BIOMOLECULAR CHEMISTRY | |
dc.contributor.department | University of Florence , , | |
dc.identifier.volume | 13 | |
dc.identifier.issue | 23 | |
dc.identifier.startpage | 6493 | |
dc.identifier.endpage | 6499 | |
dc.contributor.firstauthorID | 47687 | |