dc.contributor.author | Saylan, M | |
dc.contributor.author | Polat, A | |
dc.contributor.author | Yazici, O | |
dc.contributor.author | Kora, K | |
dc.date.accessioned | 2021-03-05T08:40:16Z | |
dc.date.available | 2021-03-05T08:40:16Z | |
dc.identifier.citation | Yazici O., Kora K., Polat A., Saylan M., "Controlled lithium discontinuation in bipolar patients with good response to long-term lithium prophylaxis", JOURNAL OF AFFECTIVE DISORDERS, cilt.80, ss.269-271, 2004 | |
dc.identifier.issn | 0165-0327 | |
dc.identifier.other | vv_1032021 | |
dc.identifier.other | av_9a1c6467-f4a2-4ce2-8bef-10dee02c2589 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/103615 | |
dc.identifier.uri | https://doi.org/10.1016/s0165-0327(03)00133-2 | |
dc.description.abstract | Background: This study aims to investigate whether the risk of recurrence following lithium discontinuation is less than reported in discontinuation of a successful, long-term prophylaxis in bipolar patients. Methods: A total of 32 bipolar patients discontinued lithium according to the controlled lithium discontinuation (CLD) protocol following a definite good response to lithium maintenance of at least 5 years. Subjects were followed for up to 9 years. Results: The total rate of recurrence was 7% in the first week, 32% in the first month, 62% in the first year, and 81% at the end of the 9th year following discontinuation. Only six of the 32 patients (19%) did not have a recurrence during the follow-up period. Conclusions: Discontinuation of lithium seems to be followed by a high rate of recurrence in bipolar patients even after good response to a long-duration illness-free period. A controlled discontinuation protocol can reduce the risks of morbidity. (C) 2003 Elsevier B.V. All rights reserved. | |
dc.language.iso | eng | |
dc.subject | Dahili Tıp Bilimleri | |
dc.subject | KLİNİK NEUROLOJİ | |
dc.subject | Klinik Tıp | |
dc.subject | Nöroloji | |
dc.subject | Klinik Tıp (MED) | |
dc.subject | Psikiyatri | |
dc.subject | Tıp | |
dc.subject | Sağlık Bilimleri | |
dc.title | Controlled lithium discontinuation in bipolar patients with good response to long-term lithium prophylaxis | |
dc.type | Makale | |
dc.relation.journal | JOURNAL OF AFFECTIVE DISORDERS | |
dc.contributor.department | , , | |
dc.identifier.volume | 80 | |
dc.identifier.startpage | 269 | |
dc.identifier.endpage | 271 | |
dc.contributor.firstauthorID | 171687 | |