Functionally Overlapping Roles of Abcg2 (Bcrp1) and Abcc2 (Mrp2) in the Elimination of Methotrexate and Its Main Toxic Metabolite 7-Hydroxymethotrexate In vivo

Date
2009
Author
van Esch, Anita
van der Kruijssen, Cornelia M. M.
van de Wetering, Koen
de Waart, Dirk R.
Wagenaar, Els
Vlaming, Maria L. H.
Pala, Zeliha
Schinkel, Alfred H.
van Tellingen, Olaf
Elferink, Ronald P. J. Oude
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Abstract
Purpose: ABCC2 (MRP2) and ABCG2 (BCRP) transport various endogenous and exogenous compounds, including many anticancer drugs, into bile, feces, and urine. We investigated the possibly overlapping roles of Abcg2 and Abcc2 in the elimination of the anticancer drug methotrexate (MTX) and its toxic metabolite 7-hydroxymethotrexate (7OH-MTX).
URI
http://hdl.handle.net/20.500.12627/104937
https://doi.org/10.1158/1078-0432.ccr-08-2940
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