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Functionally Overlapping Roles of Abcg2 (Bcrp1) and Abcc2 (Mrp2) in the Elimination of Methotrexate and Its Main Toxic Metabolite 7-Hydroxymethotrexate In vivo

dc.contributor.authorvan Esch, Anita
dc.contributor.authorvan der Kruijssen, Cornelia M. M.
dc.contributor.authorvan de Wetering, Koen
dc.contributor.authorde Waart, Dirk R.
dc.contributor.authorWagenaar, Els
dc.contributor.authorVlaming, Maria L. H.
dc.contributor.authorPala, Zeliha
dc.contributor.authorSchinkel, Alfred H.
dc.contributor.authorvan Tellingen, Olaf
dc.contributor.authorElferink, Ronald P. J. Oude
dc.date.accessioned2021-03-05T09:04:38Z
dc.date.available2021-03-05T09:04:38Z
dc.date.issued2009
dc.identifier.citationVlaming M. L. H. , Pala Z., van Esch A., Wagenaar E., de Waart D. R. , van de Wetering K., van der Kruijssen C. M. M. , Elferink R. P. J. O. , van Tellingen O., Schinkel A. H. , "Functionally Overlapping Roles of Abcg2 (Bcrp1) and Abcc2 (Mrp2) in the Elimination of Methotrexate and Its Main Toxic Metabolite 7-Hydroxymethotrexate In vivo", CLINICAL CANCER RESEARCH, cilt.15, ss.3084-3093, 2009
dc.identifier.issn1078-0432
dc.identifier.otherav_9c297c89-5ace-4e84-940e-4c98856dd2f1
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/104937
dc.identifier.urihttps://doi.org/10.1158/1078-0432.ccr-08-2940
dc.description.abstractPurpose: ABCC2 (MRP2) and ABCG2 (BCRP) transport various endogenous and exogenous compounds, including many anticancer drugs, into bile, feces, and urine. We investigated the possibly overlapping roles of Abcg2 and Abcc2 in the elimination of the anticancer drug methotrexate (MTX) and its toxic metabolite 7-hydroxymethotrexate (7OH-MTX).
dc.language.isoeng
dc.subjectOnkoloji
dc.subjectONKOLOJİ
dc.subjectKlinik Tıp
dc.subjectKlinik Tıp (MED)
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectDahili Tıp Bilimleri
dc.subjectİç Hastalıkları
dc.titleFunctionally Overlapping Roles of Abcg2 (Bcrp1) and Abcc2 (Mrp2) in the Elimination of Methotrexate and Its Main Toxic Metabolite 7-Hydroxymethotrexate In vivo
dc.typeMakale
dc.relation.journalCLINICAL CANCER RESEARCH
dc.contributor.departmentNetherlands Cancer Institute , ,
dc.identifier.volume15
dc.identifier.issue9
dc.identifier.startpage3084
dc.identifier.endpage3093
dc.contributor.firstauthorID79250


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