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dc.contributor.authorSTUER, Liesbeth
dc.contributor.authorHacioglu, MAYRAM
dc.contributor.authorCRABBE, Aurelie
dc.contributor.authorHENRY, Silke
dc.contributor.authorRIGOLE, Petra
dc.contributor.authorDHONDT, Inne
dc.contributor.authorCoenye, Tom
dc.contributor.authorTavernier, Sarah
dc.date.accessioned2021-03-05T09:10:22Z
dc.date.available2021-03-05T09:10:22Z
dc.date.issued2017
dc.identifier.citationTavernier S., CRABBE A., Hacioglu M., STUER L., HENRY S., RIGOLE P., DHONDT I., Coenye T., "Community Composition Determines Activity of Antibiotics against Multispecies Biofilms", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, cilt.61, 2017
dc.identifier.issn0066-4804
dc.identifier.othervv_1032021
dc.identifier.otherav_9ca5619a-2dee-4f86-85fe-b37cd60197c7
dc.identifier.urihttp://hdl.handle.net/20.500.12627/105253
dc.identifier.urihttps://doi.org/10.1128/aac.00302-17
dc.description.abstractIn young cystic fibrosis (CF) patients, Staphylococcus aureus is typically the most prevalent organism, while in adults, Pseudomonas aeruginosa is the major pathogen. More recently, it was observed that also Streptococcus anginosus plays an important role in exacerbations of respiratory symptoms. These species are often coisolated from CF lungs, yet little is known about whether antibiotic killing of one species is influenced by the presence of others. In the present study, we compared the activities of various antibiotics against S. anginosus, S. aureus, and P. aeruginosa when grown in monospecies biofilms with the activity observed in a multispecies biofilm. Our results show that differences in antibiotic activity against species grown in mono- and multispecies biofilms are species and antibiotic dependent. Fewer S. anginosus cells are killed by antibiotics that interfere with cell wall synthesis (amoxicillin plus sulbactam, cefepime, imipenem, meropenem, and vancomycin) in the presence of S. aureus and P. aeruginosa, while for ciprofloxacin, levofloxacin, and tobramycin, no difference was observed. In addition, we observed that the cell-free supernatant of S. aureus, but not that of P. aeruginosa biofilms, also caused this decrease in killing. Overall, S. aureus was more affected by antibiotic treatment in a multispecies biofilm, while for P. aeruginosa, no differences were observed between growth in mono- or multispecies biofilms. The results of the present study suggest that it is important to take the community composition into account when evaluating the effect of antimicrobial treatments against certain species in mixed biofilms.
dc.language.isoeng
dc.subjectTemel Bilimler
dc.subjectEczacılık
dc.subjectYaşam Bilimleri
dc.subjectTemel Eczacılık Bilimleri
dc.subjectSağlık Bilimleri
dc.subjectFarmakoloji ve Toksikoloji
dc.subjectFARMAKOLOJİ VE ECZACILIK
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectMikrobiyoloji
dc.titleCommunity Composition Determines Activity of Antibiotics against Multispecies Biofilms
dc.typeMakale
dc.relation.journalANTIMICROBIAL AGENTS AND CHEMOTHERAPY
dc.contributor.departmentGhent University , ,
dc.identifier.volume61
dc.identifier.issue9
dc.contributor.firstauthorID101457


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