Cyclooxygenase-2 gene and epithelial ovarian carcinoma risk
Date
2011Author
KARATEKE, Ates
Cakmakoglu, Bedia
Iyibozkurt, Ahmet Cem
Attar, Erkut
Kahraman, Ozlem Timirci
Attar, Rukset
Dalan, Altay Burak
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In this study, we aimed to investigate a possible association of the COX-2 polymorphisms (-765G -> C and -1195A -> G) and with the risk of developing epithelial ovarian carcinoma (EOC). COX-2 gene polymorphisms was investigated in 111 healthy women and 57 patients with EOC. Individuals who had -765 CG, -1195 AA genotype, and -765 C allele had increased risk for ovarian carcinoma (P G and -765G -> C polymorphisms in the development of EOC. To the best of our knowledge, this is the first study to show such an association.
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