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The effect of CD14 and TLR4 gene polimorphisms on asthma phenotypes in adult Turkish asthma patients: a genetic study

dc.contributor.authorKuskucu, Aysegul
dc.contributor.authorSahin, Fusun
dc.contributor.authorKaraca, Nilgun
dc.contributor.authorYildiz, Pinar
dc.contributor.authorKuskucu, Mert Ahmet
dc.contributor.authorMidilli, Kenan
dc.date.accessioned2021-03-05T09:56:34Z
dc.date.available2021-03-05T09:56:34Z
dc.identifier.citationSahin F., Yildiz P., Kuskucu A., Kuskucu M. A. , Karaca N., Midilli K., "The effect of CD14 and TLR4 gene polimorphisms on asthma phenotypes in adult Turkish asthma patients: a genetic study", BMC PULMONARY MEDICINE, cilt.14, 2014
dc.identifier.issn1471-2466
dc.identifier.othervv_1032021
dc.identifier.otherav_a0643527-f235-4ced-b273-742f343bc69b
dc.identifier.urihttp://hdl.handle.net/20.500.12627/107588
dc.identifier.urihttps://doi.org/10.1186/1471-2466-14-20
dc.description.abstractBackground: Endotoxins stimulate T helper 1 cell maturation and send a negative signal to T helper 2 polarisation. This causes a decrease IgE levels and prevents atopy (Hygiene hypothesis). It is shown that this response is under genetic control by polymorphisms in CD14 and TLR4 genes in some researchs. We aimed to investigate the effects of genetic variants of CD14 (-) and TLR4 (Asp299Gly, Thr399Ile) genes on asthma phenotypes in adults with asthma.
dc.language.isoeng
dc.subjectSağlık Bilimleri
dc.subjectGöğüs Hastalıkları ve Allerji
dc.subjectDahili Tıp Bilimleri
dc.subjectSOLUNUM SİSTEMİ
dc.subjectKlinik Tıp
dc.subjectKlinik Tıp (MED)
dc.subjectTıp
dc.titleThe effect of CD14 and TLR4 gene polimorphisms on asthma phenotypes in adult Turkish asthma patients: a genetic study
dc.typeMakale
dc.relation.journalBMC PULMONARY MEDICINE
dc.contributor.departmentIstanbul Yedikule Chest Diseases & Thoracic Surgery Training & Research Hospital , ,
dc.identifier.volume14
dc.contributor.firstauthorID43357


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