dc.contributor.author | Dincol, G. | |
dc.contributor.author | Diz-Kucukkaya, R. | |
dc.contributor.author | Bicakci, E. | |
dc.date.accessioned | 2021-03-05T10:36:37Z | |
dc.date.available | 2021-03-05T10:36:37Z | |
dc.date.issued | 2008 | |
dc.identifier.citation | Dincol G., Diz-Kucukkaya R., Bicakci E., "T-cell large granular lymphocytic leukaemia: successful response to 2-deoxycoformycin", NETHERLANDS JOURNAL OF MEDICINE, cilt.66, ss.85-87, 2008 | |
dc.identifier.issn | 0300-2977 | |
dc.identifier.other | vv_1032021 | |
dc.identifier.other | av_a3f2e85d-008c-47a2-bab6-6b5c3c6c96ea | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/109734 | |
dc.description.abstract | We report a 25-year-old woman with T-cell large granular lymphocytic leukaemia presenting with severe neutropenia, anaemia and recurrent infections with a chronic disease course. Immunophenotyping showed an expansion of CD3+, TCR gamma delta(+), CD4-, CD5+, CD7+, CD8+, CD57+ large granular lymphocytes. Clonality was demonstrated with T-gamma polymerase chain reaction analysis which revealed clonal rearrangement of the TCR gamma chain gene. Cyclosporine, granulocyte colony-stimulating factor, methothrexate and a combination of cyclophosphamide, vincristine and prednisolone failed to correct the neutropenia and the anaemia. Finally, treatment with 2-deoxycoformycin resulted in both clinical and haemotological complete responses, despite molecular evidence of the persistence of the abnormal T-cell clone. | |
dc.language.iso | eng | |
dc.subject | TIP, GENEL & İÇECEK | |
dc.subject | Klinik Tıp | |
dc.subject | Klinik Tıp (MED) | |
dc.subject | Tıp | |
dc.subject | Sağlık Bilimleri | |
dc.subject | Temel Tıp Bilimleri | |
dc.title | T-cell large granular lymphocytic leukaemia: successful response to 2-deoxycoformycin | |
dc.type | Makale | |
dc.relation.journal | NETHERLANDS JOURNAL OF MEDICINE | |
dc.contributor.department | İstanbul Üniversitesi , , | |
dc.identifier.volume | 66 | |
dc.identifier.issue | 2 | |
dc.identifier.startpage | 85 | |
dc.identifier.endpage | 87 | |
dc.contributor.firstauthorID | 186449 | |