dc.contributor.author | Kurnaz-Gomleksiz, O. | |
dc.contributor.author | Ozturk, O. | |
dc.contributor.author | Ermis-Karaali, Z. | |
dc.contributor.author | Aslan, E. I. | |
dc.contributor.author | Tokat, B. | |
dc.contributor.author | Yilmaz-Aydogan, Hülya | |
dc.contributor.author | Yanar, F. | |
dc.date.accessioned | 2021-03-05T10:38:12Z | |
dc.date.available | 2021-03-05T10:38:12Z | |
dc.date.issued | 2016 | |
dc.identifier.citation | Kurnaz-Gomleksiz O., Tokat B., Aslan E. I. , Yanar F., Ermis-Karaali Z., Ozturk O., Yilmaz-Aydogan H., "Can rs3767140 SNP of the perlecan (HSPG2) gene affect the diabetes mellitus through the dyslipidemia?", CELLULAR AND MOLECULAR BIOLOGY, cilt.62, ss.35-39, 2016 | |
dc.identifier.issn | 0145-5680 | |
dc.identifier.other | vv_1032021 | |
dc.identifier.other | av_a421bc75-9ea4-40f9-b885-9a950c4514b4 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/109825 | |
dc.identifier.uri | https://doi.org/10.14715/cmb/2016.62.8.6 | |
dc.description.abstract | Perlecan (HSPG2) play an important role in the lipoprotein metabolisms. The G allele of the HSPG2-rs3767140 may affect the binding of heparan sulfate (HS) chains and hence cause loss of HS from the basement membrane. HSPG2-rs3767140 was studied in 60 T2DM patients and 109 healthy controls. In diabetic patients HSPG2-rs3767140 T variant allele carriers (TT+GT) have decreased fasting plasma glucose (FPG) and serum LDL-C levels (p=0.071 and p=0.060, respectively) versus GG genotype carriers. Moreover, in both of the two groups in which the T allele carriers HDL-cholesterol levels tend to be high. We investigated that the HSPG2-rs3767140 promoted to the dyslipidemic phenotype in the type 2 diabetes mellitus (T2DM) patients. We suggest that the HSPG2-rs3767140 might be associated with the decreased FPG and LDL-C and with the increased HDL-C in diabetics. Therefore, the HSPG2-rs3767140 might be a protective for the diabetes mellitus due to its ameliorating effect on the dyslipidemic phenotype. | |
dc.language.iso | eng | |
dc.subject | Biochemistry, Genetics and Molecular Biology (miscellaneous) | |
dc.subject | Sağlık Bilimleri | |
dc.subject | Temel Tıp Bilimleri | |
dc.subject | Histoloji-Embriyoloji | |
dc.subject | Yaşam Bilimleri | |
dc.subject | Moleküler Biyoloji ve Genetik | |
dc.subject | Sitogenetik | |
dc.subject | Temel Bilimler | |
dc.subject | Clinical Biochemistry | |
dc.subject | Cell Biology | |
dc.subject | Cancer Research | |
dc.subject | Molecular Biology | |
dc.subject | Drug Discovery | |
dc.subject | Aging | |
dc.subject | General Biochemistry, Genetics and Molecular Biology | |
dc.subject | Biochemistry | |
dc.subject | Structural Biology | |
dc.subject | Life Sciences | |
dc.subject | BİYOKİMYA VE MOLEKÜLER BİYOLOJİ | |
dc.subject | Moleküler Biyoloji ve Genetik | |
dc.subject | Yaşam Bilimleri (LIFE) | |
dc.subject | HÜCRE BİYOLOJİSİ | |
dc.subject | Tıp | |
dc.title | Can rs3767140 SNP of the perlecan (HSPG2) gene affect the diabetes mellitus through the dyslipidemia? | |
dc.type | Makale | |
dc.relation.journal | CELLULAR AND MOLECULAR BIOLOGY | |
dc.contributor.department | İstanbul Üniversitesi , , | |
dc.identifier.volume | 62 | |
dc.identifier.issue | 8 | |
dc.identifier.startpage | 35 | |
dc.identifier.endpage | 39 | |
dc.contributor.firstauthorID | 233693 | |