dc.contributor.author | Vatankulu, Betül | |
dc.contributor.author | Cengiz, Mahir | |
dc.contributor.author | Sonmezoglu, Kerim | |
dc.contributor.author | Kocael, Pinar | |
dc.contributor.author | Kocael, Ahmet | |
dc.contributor.author | Simsek, Osman | |
dc.contributor.author | Kemik, Ahu | |
dc.contributor.author | Ulualp, Kenan | |
dc.contributor.author | Halac, Metin | |
dc.date.accessioned | 2021-03-05T10:49:13Z | |
dc.date.available | 2021-03-05T10:49:13Z | |
dc.date.issued | 2016 | |
dc.identifier.citation | Kocael A., Vatankulu B., Simsek O., Cengiz M., Kemik A., Kocael P., Halac M., Sonmezoglu K., Ulualp K., "Comparison of F-18-fluorodeoxyglucose PET/CT findings with vascular endothelial growth factors and receptors in colorectal cancer", TUMOR BIOLOGY, cilt.37, ss.3871-3877, 2016 | |
dc.identifier.issn | 1010-4283 | |
dc.identifier.other | av_a522cd03-4ca7-4ac9-a5db-afec3e53eb6c | |
dc.identifier.other | vv_1032021 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/110434 | |
dc.identifier.uri | https://doi.org/10.1007/s13277-015-4218-0 | |
dc.description.abstract | The purpose of this study was to evaluate the association of F-18-fluorodeoxyglucose (FDG)-PET/CT findings with the vascular endothelial growth factor (VEGF) family and its receptor (VEGFR) levels in metastatic and nonmetastatic colorectal cancer (CRC). Fluorine-18 FDG-PET/CT scans were performed for initial staging and restaging of patients with CRC. FDG-PET/CT findings of tumor (such as the presence of a primary tumor, the lymphatic or distance metastases, and the maximum standardized uptake value (SUVmax) of the primary tumor), serum VEGF A-C-D-E levels, and serum VEGF receptor 1-2-3 levels were analyzed. A total of 63 patients were included into the study (35 males, mean age 61.3 +/- 11.9 years). Patients were divided into two groups, based on positive and negative PET/CT findings. Patients were also categorized according to the presence of metastasis. All evaluated parameters were significantly higher in the PET/CT-positive group than the PET/CT-negative group (p < 0.001). All those parameters were also positively correlated with each other. The highest correlation for SUVmax of primary tumor was found with VEGFR-3 (p < 0.001, r = 0.665). Patients with metastases had high levels of VEGF-D, VEGF-A, VEGF-C, VEGF-E, and VEGFR-3 than those without metastases. These parameters had better specificity and sensitivity values than the SUVmax of the primary tumor for detection of metastases. However, VEGF-D was the best indicator of metastasis in all of those parameters (VEGF-D vs SUVmax; sensitivity 100 vs 100 %; specificity 76 vs 76 %; AUC 0.903 vs 0.835; p < 0.001, respectively). Vascular endothelial growth factor family and its receptors were significantly higher in metastatic CRC patients. VEGF-D was the best indicator of metastasis than all VEGF family, VEGFR-3, and primary tumor SUVmax. VEGF family (A-C-D-E) and VEGFR-3 may help to determine the prognosis and management of CRC. | |
dc.language.iso | eng | |
dc.subject | Sağlık Bilimleri | |
dc.subject | Onkoloji | |
dc.subject | Dahili Tıp Bilimleri | |
dc.subject | İç Hastalıkları | |
dc.subject | Tıp | |
dc.subject | Klinik Tıp (MED) | |
dc.subject | Klinik Tıp | |
dc.subject | ONKOLOJİ | |
dc.title | Comparison of F-18-fluorodeoxyglucose PET/CT findings with vascular endothelial growth factors and receptors in colorectal cancer | |
dc.type | Makale | |
dc.relation.journal | TUMOR BIOLOGY | |
dc.contributor.department | İstanbul Üniversitesi , , | |
dc.identifier.volume | 37 | |
dc.identifier.issue | 3 | |
dc.identifier.startpage | 3871 | |
dc.identifier.endpage | 3877 | |
dc.contributor.firstauthorID | 83839 | |