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dc.contributor.authorCanillioglu, Yasemin Ersoy
dc.contributor.authorERCAN, FERİHA
dc.contributor.authorUmay, Cenk
dc.contributor.authorDemiralp-Eksioglu, Emel
dc.contributor.authorSenturk, Gozde Erkanli
dc.date.accessioned2021-03-05T11:15:49Z
dc.date.available2021-03-05T11:15:49Z
dc.date.issued2012
dc.identifier.citationSenturk G. E. , Canillioglu Y. E. , Umay C., Demiralp-Eksioglu E., ERCAN F., "Distribution of Zonula Occludens-1 and Occludin and alterations of testicular morphology after in utero radiation and postnatal hyperthermia in rats", INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, cilt.93, ss.438-449, 2012
dc.identifier.issn0959-9673
dc.identifier.otherav_a75190bc-7265-49ec-8673-d97a188b688c
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/111865
dc.identifier.urihttps://doi.org/10.1111/j.1365-2613.2012.00844.x
dc.description.abstractIn utero irradiation (IR) and postnatal hyperthermia (HT) exposure cause infertility by decreasing spermatogenic colony growth and the number of sperm in rats. Four groups were used: (i) Control group, (ii) HT group (rats exposed to hyperthermia on the 10th postnatal day), (iii) IR group (rats exposed to IR on the 17th gestational day) and (iv) IR + HT group. Three and six months after the procedures testes were examined by light and electron microscopy. Some degenerated tubules in the HT group, many vacuoles in spermatogenic cells and degenerated tight junctions in the IR group, atrophic tubules and severe degeneration of tight junctions in the IR + HT group were observed. ZO-1 and occludin immunoreactivity were decreased and disorganized in the HT and IR groups and absent in the IR + HT group. The increase in the number of apoptotic cells was accompanied by a time-dependent decrease in haploid, diploid and tetraploid cells in all groups. Degenerative findings were severe after 6 months in all groups. The double-hit model may represent a Sertoli cell only model of infertility due to a decrease in spermatogenic cell and alterated blood-testis barrier proteins in rat.
dc.language.isoeng
dc.subjectPatoloji
dc.subjectYaşam Bilimleri
dc.subjectTemel Bilimler
dc.subjectTemel Tıp Bilimleri
dc.subjectCerrahi Tıp Bilimleri
dc.subjectBiyokimya
dc.subjectSağlık Bilimleri
dc.subjectTıp
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectBiyoloji ve Biyokimya
dc.subjectPATOLOJİ
dc.titleDistribution of Zonula Occludens-1 and Occludin and alterations of testicular morphology after in utero radiation and postnatal hyperthermia in rats
dc.typeMakale
dc.relation.journalINTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY
dc.contributor.departmentMarmara Üniversitesi , ,
dc.identifier.volume93
dc.identifier.issue6
dc.identifier.startpage438
dc.identifier.endpage449
dc.contributor.firstauthorID207141


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