Telomeric DNA: Marker for human prostate cancer development?
Date
1998Author
Chung , L.W.K.
ÖZEN, Mustafa
Narayanan , A.R.
von Eschenbach , A.C.
Pathak, S.
Imam, S.A.
Datar, R.H.
Multani , A.S.
Metadata
Show full item recordAbstract
BACKGROUND. Telomeres that protect chromosomes at both ends are shortened with each somatic cell division through replication-dependent sequence loss at DNA termini. The chromosomes with shortened telomeres tend to become unstable, leading to cell death. Due largely to reactivation/upregulation of telomerase, a ribonucleoprotein that adds nucleotide sequences onto chromosome ends, cancer cells become immortal and neoplastically transformed.
Collections
- Makale [92796]