dc.contributor.author | Guzeldemirci, Nuray Ulusoy | |
dc.contributor.author | Gursoy, Elif | |
dc.date.accessioned | 2021-03-05T11:51:11Z | |
dc.date.available | 2021-03-05T11:51:11Z | |
dc.date.issued | 2007 | |
dc.identifier.citation | Gursoy E., Guzeldemirci N. U. , "Synthesis and primary cytotoxicity evaluation of new imidazo[2,1-b]thiazole derivatives", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, cilt.42, ss.320-326, 2007 | |
dc.identifier.issn | 0223-5234 | |
dc.identifier.other | av_aa346ce7-3451-4e26-a992-79193e0a7fa9 | |
dc.identifier.other | vv_1032021 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/113654 | |
dc.identifier.uri | https://doi.org/10.1016/j.ejmech.2006.10.012 | |
dc.description.abstract | A series of arylidenehydrazides (3a-3i) were synthesized from [6-(4-bromophenyl)imidazo[2,1-b] thiazol-3-yl] acetic acid hydrazide. The structures of new compounds were determined by analytical and spectral (IR, H-1 NMR, C-13 NMR, EIMS) methods. The synthesized compounds (3a-3i) were evaluated in the National Cancer Institute's 3-cell line, one dose in vitro primary cytotoxicity assay. Compounds 3a-3c, 3h and 3i which passed the criteria for activity in this assay were scheduled automatically for evaluation against the full panel of 60 human tumour cell lines at a minimum of five concentrations at 10-fold dilutions. Compounds 3c demonstrated the most marked effects on a prostate cancer cell line (PC-3, log(10) GI(50) value < -8.00). (c) 2006 Elsevier Masson SAS. All rights reserved. | |
dc.language.iso | eng | |
dc.subject | Temel Eczacılık Bilimleri | |
dc.subject | Yaşam Bilimleri | |
dc.subject | Biyokimya | |
dc.subject | Temel Bilimler | |
dc.subject | Sağlık Bilimleri | |
dc.subject | Eczacılık | |
dc.subject | Yaşam Bilimleri (LIFE) | |
dc.subject | Farmakoloji ve Toksikoloji | |
dc.subject | FARMAKOLOJİ VE ECZACILIK | |
dc.subject | Temel Bilimler (SCI) | |
dc.subject | Kimya | |
dc.subject | KİMYA, TIP | |
dc.title | Synthesis and primary cytotoxicity evaluation of new imidazo[2,1-b]thiazole derivatives | |
dc.type | Makale | |
dc.relation.journal | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | |
dc.contributor.department | , , | |
dc.identifier.volume | 42 | |
dc.identifier.issue | 3 | |
dc.identifier.startpage | 320 | |
dc.identifier.endpage | 326 | |
dc.contributor.firstauthorID | 46816 | |