dc.contributor.author | Melikoglu, Gulay | |
dc.contributor.author | Ozsoy, Nurten | |
dc.contributor.author | Aksoy-Sagirli, Pınar | |
dc.contributor.author | Ecevit-Genc, Gülay | |
dc.date.accessioned | 2021-03-05T11:52:16Z | |
dc.date.available | 2021-03-05T11:52:16Z | |
dc.identifier.citation | Aksoy-Sagirli P., Ozsoy N., Ecevit-Genc G., Melikoglu G., "In vitro antioxidant activity, cyclooxygenase-2, thioredoxin reductase inhibition and DNA protection properties of Teucrium sandrasicum L.", Industrial Crops and Products, cilt.74, ss.545-550, 2015 | |
dc.identifier.issn | 0926-6690 | |
dc.identifier.other | vv_1032021 | |
dc.identifier.other | av_aa4e1b3f-da6a-45d0-97a1-f65e9a776a5a | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/113723 | |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84930941231&origin=inward | |
dc.identifier.uri | https://doi.org/10.1016/j.indcrop.2015.05.025 | |
dc.description.abstract | © 2015 Elsevier B.V.The aerial parts of Teucrium sandrasicum L. (Lamiaceae), an endemic species of the Turkish flora, are widely used in the daily diet. The plant is also valued as a traditional medicine and is used for diuretic, diaphoretic, tonic, antipyretic, antidiabetic, antispasmodic, and cholagogic purposes. This study investigated a methanolic extract of aerial parts of T. sandrasicum for its antioxidant and anti-inflammatory effects, inhibition of thioredoxin reductase, and protection against DNA damage. The extract showed inhibitory activity against FeCl3/ascorbic acid induced phosphatidylcholine liposome oxidation (EC50=1.49±0.03mg/mL), quenched stable DPPH (EC50=1.05±0.03mg/mL), superoxide anion (EC50=1.20±0.06mg/mL), and ABTS cation radicals (EC50=1.73±0.01mg/mL). The extract also acted as a reductant, as determined by the FRAP value (2.66±0.21mM/L Fe2+), indicating its potential as an antioxidant. The T. sandrasicum species was determined to be a rich source of flavonoids (104.39±1.37mg/g), which are likely to serve as antioxidant, anti-inflammatory, and cancer chemoprevention agents. The extract was strongly inhibitory against both cyclooxygenase-2 (COX-2) (EC50=1.18±0.03mg/mL) and thioredoxin reductase (0.90±0.02mg/mL), and it significantly and dose-dependently decreased the amount of nicked DNA, as well as increased the natural form of DNA. | |
dc.language.iso | eng | |
dc.subject | Toprak ve Bitki Besleme | |
dc.subject | Toprak Verimliliği ve Gübreleme | |
dc.subject | Ziraat | |
dc.subject | Tarımsal Bilimler | |
dc.subject | TARIM BİLİMİ | |
dc.subject | Tarım ve Çevre Bilimleri (AGE) | |
dc.subject | Tarım Bilimleri | |
dc.subject | TARIM MÜHENDİSLİĞİ | |
dc.title | In vitro antioxidant activity, cyclooxygenase-2, thioredoxin reductase inhibition and DNA protection properties of Teucrium sandrasicum L. | |
dc.type | Makale | |
dc.relation.journal | Industrial Crops and Products | |
dc.contributor.department | İstanbul Üniversitesi , Eczacılık Fakültesi , Eczacılık Meslek Bilimleri Bölümü | |
dc.identifier.volume | 74 | |
dc.identifier.startpage | 545 | |
dc.identifier.endpage | 550 | |
dc.contributor.firstauthorID | 2201198 | |