dc.contributor.author | Eronat, Allison P. | |
dc.contributor.author | Bugra, Zehra | |
dc.contributor.author | Coskunpinar, Ender | |
dc.contributor.author | Ozturk, Oguz | |
dc.contributor.author | Ilikay, Serap | |
dc.contributor.author | Kurnaz-Gomleksiz, Ozlem | |
dc.contributor.author | Yilmaz-Aydogan, Hulya | |
dc.date.accessioned | 2021-03-05T11:55:26Z | |
dc.date.available | 2021-03-05T11:55:26Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | Ilikay S., Coskunpinar E., Kurnaz-Gomleksiz O., Bugra Z., Eronat A. P. , Ozturk O., Yilmaz-Aydogan H., "Effects of common variations of NOS3 and CAV1 genes on hypercholesterolemic profile in coronary heart disease", ISTANBUL JOURNAL OF PHARMACY, cilt.49, ss.53-60, 2019 | |
dc.identifier.other | vv_1032021 | |
dc.identifier.other | av_aa854aa7-3222-4c9b-b474-9384ac49070f | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/113870 | |
dc.identifier.uri | https://doi.org/10.26650/istanbuljpharm.2019.18010 | |
dc.description.abstract | Caveolin-1 (CAV-1) plays a crucial role in endothelial-nitric oxide synthase (eNOS) enzymatic activity. Therefore, CAV-1 and eNOS interactions have a significant impact on endothelial dysfunction, cholesterol levels, and atherosclerosis. We investigated the critical variations in NOS3 and CAV1 genes in this case-control study to determine the relations between the coronary heart disease (CHD) risk factors. The NOS3-rs1799983, CAV-1 rs3840634, and rs3807990 variations were analyzed in 76 CHD patients and 91 controls using the polymerase chain reaction. Mean serum Total-cholesterol levels were significantly higher in CHD patients with the CAV-1 rs3807990-T allele than in patients with CC genotype (p=0.017). There was a statistically significant correlation between the rs3807990-T allele and hypercholesterolemia in the CHD group (p=0.008). The multivariate analysis confirmed that the CAV-1 rs3807990-T allele (p=0.011) is a risk factor for hypercholesterolemia. Moreover, the serum HDL-Cholesterol level was detected to be higher in patients carrying both CAV1-rs3807990-T and NOS3-rs1799983-T alleles than those with the CAV-1 rs3807990-CC/NOS3-rs1799983-GG genotype subgroup (p=0.013). These results suggested that the genetic variations of CAV-1 rs3807990 and NOS3-rs1799983 may contribute to the increased hypercholesterolemia risk and thus on the development of CHD. | |
dc.language.iso | eng | |
dc.subject | Temel Bilimler | |
dc.subject | Eczacılık | |
dc.subject | Yaşam Bilimleri | |
dc.subject | Temel Eczacılık Bilimleri | |
dc.subject | Sağlık Bilimleri | |
dc.subject | Yaşam Bilimleri (LIFE) | |
dc.subject | Farmakoloji ve Toksikoloji | |
dc.subject | FARMAKOLOJİ VE ECZACILIK | |
dc.title | Effects of common variations of NOS3 and CAV1 genes on hypercholesterolemic profile in coronary heart disease | |
dc.type | Makale | |
dc.relation.journal | ISTANBUL JOURNAL OF PHARMACY | |
dc.contributor.department | Altınbaş Üniversitesi , , | |
dc.identifier.volume | 49 | |
dc.identifier.issue | 2 | |
dc.identifier.startpage | 53 | |
dc.identifier.endpage | 60 | |
dc.contributor.firstauthorID | 10573 | |