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dc.contributor.authorCukurova, Zafer
dc.contributor.authorHergunsel, Oya
dc.contributor.authorTekdos, Yasemin
dc.contributor.authorDemir, Guray
dc.contributor.authorUhri, Mehmet
dc.contributor.authorGEDİKBAŞI, Asuman
dc.contributor.authorEren, Gulay
dc.date.accessioned2021-03-02T21:44:52Z
dc.date.available2021-03-02T21:44:52Z
dc.date.issued2012
dc.identifier.citationCukurova Z., Hergunsel O., Eren G., GEDİKBAŞI A., Uhri M., Demir G., Tekdos Y., "The Effect of Pomegranate Juice on Diabetes-Related Oxidative Stress in Rat Lung", TURKIYE KLINIKLERI TIP BILIMLERI DERGISI, cilt.32, sa.2, ss.444-452, 2012
dc.identifier.issn1300-0292
dc.identifier.othervv_1032021
dc.identifier.otherav_08a7ff72-9946-40dd-9719-04f9aaabb07e
dc.identifier.urihttp://hdl.handle.net/20.500.12627/11633
dc.identifier.urihttps://doi.org/10.5336/medsci.2011-24472
dc.description.abstractObjective: It is known that diabetes leads to depletion of the cellular antioxidant defense system and this causes the organ injuries related to the diabetic complications. Antioxidants have been shown to reduce indices of oxidative stress measures in experimental disease models and in humans. The present study was designed to evaluate the oxidative stress in lungs as well as the therapeutic effect of pomegranate juice (PJ), as an antioxidant, in rats with streptozotocin-induced diabetes. Material and Methods: Twenty seven rats were enrolled in the study where diabetes was induced by streptozotocin injection. Rats were treated with either PJ or saline for 10 weeks, and their lungs were harvested for histologic and immunohistochemical evaluation at the end. Protein carbonyl content (PCC), sialic acid (SA), superoxide dismutase (SOD) and reduced glutathione (GSH) activities were measured in the pulmonary tissue as well as the presence of endothelial nitric oxide synthase (eNOS), through immunohistochemistry. Results: The pulmonary tissue in diabetic rats showed oxidative alterations related to the streptozotocin treatment. There was increased eNOS expressions in diabetic lungs, but PJ treatment diminished both eNOS expressions and inflammatory changes in pulmonary tissue. PCC and SA levels were higher in diabetic lungs (p<0.01) whereas SOD was lower (p=0.021) and GSH did not change significantly in comparison to PJ-treated diabetic group (p=0.374). Conclusion: The PJ treatment effectively reduced the oxidative stress and contributed to tissue recovery in experimental diabetic lungs. These findings would be of clinical relevance.
dc.language.isoeng
dc.subjectTıp
dc.subjectTIP, GENEL & İÇECEK
dc.subjectKlinik Tıp
dc.subjectKlinik Tıp (MED)
dc.subjectSağlık Bilimleri
dc.subjectTemel Tıp Bilimleri
dc.titleThe Effect of Pomegranate Juice on Diabetes-Related Oxidative Stress in Rat Lung
dc.typeMakale
dc.relation.journalTURKIYE KLINIKLERI TIP BILIMLERI DERGISI
dc.contributor.departmentBakirkoy Dr. Sadi Konuk Research & Training Hospital , ,
dc.identifier.volume32
dc.identifier.issue2
dc.identifier.startpage444
dc.identifier.endpage452
dc.contributor.firstauthorID2215016


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