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dc.contributor.authorOzluk, Yasemin
dc.contributor.authorAlp-Yildirim, F. Ilkay
dc.contributor.authorBekpinar, Seldağ
dc.contributor.authorUydes-Dogan, Birsel Sönmez
dc.contributor.authorTepe, Ozge
dc.contributor.authorGiris, Murat
dc.contributor.authorUnlucerci, Yesim
dc.contributor.authorKabasakal, Merve
dc.contributor.authorAycan-Ustyol, Esra
dc.contributor.authorUysal, Mujdat
dc.date.accessioned2021-03-05T12:41:29Z
dc.date.available2021-03-05T12:41:29Z
dc.date.issued2017
dc.identifier.citationAycan-Ustyol E., Kabasakal M., Bekpinar S., Alp-Yildirim F. I. , Tepe O., Giris M., Ozluk Y., Unlucerci Y., Uydes-Dogan B. S. , Uysal M., "Vascular function and arginine and dimethylarginines in gentamicin-induced renal failure: a possible effect of heme oxygenase 1 inducer hemin", CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, cilt.95, ss.1406-1413, 2017
dc.identifier.issn0008-4212
dc.identifier.otherav_ae5fcd18-08ca-4d92-9fda-785c31959328
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/116342
dc.identifier.urihttps://doi.org/10.1139/cjpp-2016-0578
dc.description.abstractIncreased oxidative stress and disturbance in nitric oxide bioavailability lead to endothelial dysfunction and cardiovascular complication in renal disease. Gentamicin (GM), a commonly used antibiotic, exhibits a toxic effect on renal proximal tubules. Prevention of its nephrotoxicity is important. Therefore, we investigated whether heme oxygenase 1 HO-1) induction influenced kidney and vascular function in GM-administered rats. GM (100 mg.kg(-1).day(-1); i.p.) was given to rats alone or together with hemin (20 mg.kg(-1) on alternate days; i.p.) for 14 days. Plasma and kidney L-arginine, asymmetric dimethylarginine (ADMA), and symmetric dimethylarginine (SDMA) as well as kidney 4-hydroxynonenal (HNE) levels and myeloperoxidase (MPO) activity were measured. Histopathological examinations of kidney and relaxation and contraction responses of aorta were also examined. GM increased serum SDMA, urea nitrogen (BUN), and creatinine levels and caused histopathological alterations in the kidney. GM elevated HO-1 protein and mRNA expressions, 4-HNE level, and MPO activity and decreased antioxidant enzyme activities and L-arginine levels in the kidney. Decreased relaxation and contraction were detected in the aorta. Hemin restored renal oxidative stress and inflammatory changes together with vascular dysfunction, but did not affect SDMA, BUN, or creatinine levels. We conclude that HO-1 induction may be effective in improving renal oxidative stress, inflammation, and vascular dysfunction mediated by GM.
dc.language.isoeng
dc.subjectBiyokimya
dc.subjectFizyoloji
dc.subjectEczacılık
dc.subjectTemel Eczacılık Bilimleri
dc.subjectYaşam Bilimleri
dc.subjectTemel Bilimler
dc.subjectFARMAKOLOJİ VE ECZACILIK
dc.subjectFarmakoloji ve Toksikoloji
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectFİZYOLOJİ
dc.subjectBiyoloji ve Biyokimya
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectTemel Tıp Bilimleri
dc.titleVascular function and arginine and dimethylarginines in gentamicin-induced renal failure: a possible effect of heme oxygenase 1 inducer hemin
dc.typeMakale
dc.relation.journalCANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
dc.contributor.departmentİstanbul Üniversitesi , ,
dc.identifier.volume95
dc.identifier.issue12
dc.identifier.startpage1406
dc.identifier.endpage1413
dc.contributor.firstauthorID29817


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