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Sex-dependent changes in blood-brain barrier permeability in epileptic rats following acute hyperosmotic exposure

dc.contributor.authorKucuk, Mutlu
dc.contributor.authorKaya, Mehmet
dc.contributor.authorOztas, Baria
dc.date.accessioned2021-03-05T12:52:29Z
dc.date.available2021-03-05T12:52:29Z
dc.date.issued2001
dc.identifier.citationOztas B., Kucuk M., Kaya M., "Sex-dependent changes in blood-brain barrier permeability in epileptic rats following acute hyperosmotic exposure", PHARMACOLOGICAL RESEARCH, cilt.43, ss.469-472, 2001
dc.identifier.issn1043-6618
dc.identifier.otherav_af5e7b5b-f225-4195-847a-e244a82ae64b
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/116943
dc.identifier.urihttps://doi.org/10.1006/phrs.2001.0797
dc.description.abstractOsmotic and ionic balance in the central nervous system is especially regulated by solutes and water transport across the blood-brain barrier. The aim of this study was to investigate the effect of systemic hyperosmolarity on the blood-brain barrier permeability in both sexes after experimentally induced seizures. Eight groups of rats were studied: Group I: female control; Group II: male control; Group III: hyperosmotic female; Group IV: hyperosmotic male; Group V: non-hyperosmotic female + seizure; Group VI: non-hyperosmotic male + seizure; Group VII: hyperosmotic female + seizure; Group VIII: hyperosmotic male + seizure. In female rats with pentylenetetrazol-induced seizures, the extravasation of Evans-blue was greater in the brains of hyperosmotic animals than that in normal rats (P < 0.02). However, in male rats, the extravasation of Evans-blue was similar in the brains of hyperosmotic male rats and normal rats after seizure.
dc.language.isoeng
dc.subjectTemel Bilimler
dc.subjectSağlık Bilimleri
dc.subjectFARMAKOLOJİ VE ECZACILIK
dc.subjectFarmakoloji ve Toksikoloji
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectEczacılık
dc.subjectTemel Eczacılık Bilimleri
dc.subjectYaşam Bilimleri
dc.titleSex-dependent changes in blood-brain barrier permeability in epileptic rats following acute hyperosmotic exposure
dc.typeMakale
dc.relation.journalPHARMACOLOGICAL RESEARCH
dc.contributor.departmentİstanbul Üniversitesi , Deneysel Tıp Araştırma Enstitüsü , Laboratuvar Hayvanları Bilimi Anabilim Dalı
dc.identifier.volume43
dc.identifier.issue5
dc.identifier.startpage469
dc.identifier.endpage472
dc.contributor.firstauthorID5635


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