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dc.contributor.authorTiryaki, D
dc.contributor.authorSener, A
dc.contributor.authorYetkin, G
dc.contributor.authorBermek, E
dc.contributor.authorYalcintepe, Leman
dc.contributor.authorTurker-Sener, L
dc.date.accessioned2021-03-05T13:02:56Z
dc.date.available2021-03-05T13:02:56Z
dc.date.issued2005
dc.identifier.citationYalcintepe L., Turker-Sener L., Sener A., Yetkin G., Tiryaki D., Bermek E., "Changes in NAD/ADP-ribose metabolism in rectal cancer.", Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, cilt.38, ss.361-5, 2005
dc.identifier.issn0100-879X
dc.identifier.othervv_1032021
dc.identifier.otherav_b03a42f6-6e6f-4123-b9ca-e6e4a3f22340
dc.identifier.urihttp://hdl.handle.net/20.500.12627/117502
dc.identifier.urihttps://doi.org/10.1590/s0100-879x2005000300006
dc.description.abstractThe extent of ADP-ribosylation in rectal cancer was compared to that of the corresponding normal rectal tissue. Twenty rectal tissue fragments were collected during surgery from patients diagnosed as having rectal cancer on the basis of pathology results. The levels of ADP-ribosylation in rectum cancer tissue samples (95.9 +/- 22.1 nmol/ml) was significantly higher than in normal tissues (11.4 +/- 14 nmol/ml). The level of NAD(+) glycohydrolase and ADP-ribosyl cyclase activities in rectal cancer and normal tissue samples were measured. Cancer tissues had significantly higher NAD(+) glycohydrolase and ADP-ribosyl cyclase activities than the control tissues (43.3 +/- 9.1 vs 29.2 +/- 5.2 and 6.2 +/- 1.6 vs 1.6 +/- 0.4 nmol mg(-1) min(-1)). Approximately 75% of the NAD(+) concentration was consumed as substrate in rectal cancer, with changes in NAD(+)/ADP-ribose metabolism being observed. When [C-14]-ADP-ribosylated tissue samples were subjected to SDS-PAGE, autoradiographic analysis revealed that several proteins were ADP-ribosylated in rectum tissue. Notably, the radiolabeling of a 113-kDa protein was remarkably greater than that in control tissues. Poly(ADP)ribosylation of the 113-kDa protein in rectum cancer tissues might be enhanced with its proliferative activity, and poly(ADP)-ribosylation of the same protein in rectum cancer patients might be an indicator of tumor diagnosis.
dc.language.isoeng
dc.subjectDahili Tıp Bilimleri
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectTIP, ARAŞTIRMA VE DENEYSEL
dc.subjectKlinik Tıp
dc.subjectKlinik Tıp (MED)
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectTemel Tıp Bilimleri
dc.subjectBiyokimya
dc.subjectTıbbi Biyoloji
dc.subjectTemel Bilimler
dc.subjectYaşam Bilimleri
dc.subjectTıbbi Ekoloji ve Hidroklimatoloji
dc.subjectBİYOLOJİ
dc.subjectBiyoloji ve Biyokimya
dc.titleChanges in NAD/ADP-ribose metabolism in rectal cancer.
dc.typeMakale
dc.relation.journalBrazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas
dc.contributor.department, ,
dc.identifier.volume38
dc.identifier.issue3
dc.identifier.startpage361
dc.identifier.endpage5
dc.contributor.firstauthorID57468


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