dc.contributor.author | Konukoglu, Dildar | |
dc.contributor.author | Kalayci, Rivaze | |
dc.contributor.author | Uzun, Hafize | |
dc.contributor.author | Arican, Nadir | |
dc.contributor.author | Kaya, Mehmet | |
dc.contributor.author | SÖZER, Volkan | |
dc.contributor.author | Gelisgen, Remise | |
dc.contributor.author | Tabak, Omur | |
dc.date.accessioned | 2021-03-05T13:09:34Z | |
dc.date.available | 2021-03-05T13:09:34Z | |
dc.date.issued | 2013 | |
dc.identifier.citation | SÖZER V., Uzun H., Gelisgen R., Kaya M., Kalayci R., Tabak O., Arican N., Konukoglu D., "The effects of atorvastatin on oxidative stress in L-NAME-treated rats", SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION, cilt.73, ss.591-597, 2013 | |
dc.identifier.issn | 0036-5513 | |
dc.identifier.other | vv_1032021 | |
dc.identifier.other | av_b0d5c187-524e-490f-a1f2-ef091ec6b785 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/117839 | |
dc.identifier.uri | https://doi.org/10.3109/00365513.2013.828241 | |
dc.description.abstract | Objectives. Current evidence suggests that the beneficial vascular effects of statins are not limited to the statins' lipid-lowering properties; these drugs can also improve vascular endothelial cell function. N omega-nitro-l-arginine methyl ester (L-NAME) is a potent synthetic nitric oxide inhibitor, and long-term oral L-NAME treatment is used to induce vascular lesions in experimental animal models. Methods. We determined the effects of statins on protein carbonyl (PCO), lipid hydroperoxides (LHP), oxidized low-density lipoproteins (ox-LDL) and antioxidants such as paraoxonase 1 (PON1) and total thiols (T-SH) in long-term L-NAME-treated rats. Adult male Wistar rats were divided into three groups, namely, control, L-NAME-treated (1 mg/mL in drinking water for three weeks), and atorvastatin plus L-NAME-treated (4 mg/kg/day atorvastatin for 1 week during the third week of L-NAME treatment) groups. Results. In the L-NAME group, the ox-LDL, LHP and PCO were higher and the PON1 and T-SH were lower than the concentrations observed for the controls. When compared with the L-NAME group, the L-NAME plus atorvastatin group had significantly lower ox-LDL and LHP and higher PON1 activities. Additionally, the elevated total cholesterol (TC) and low-density lipoprotein-C (LDL-C) in the L-NAME group were decreased by atorvastatin administration. TC and LDL-C were positively correlated with ox-LDL and LHP and negatively correlated with PON1 in all groups. High-density lipoprotein-C (HDL-C) was negatively correlated with ox-LDL. Conclusion. PON1 prevents LDL oxidation and inactivates LDL-derived oxidized phospholipids; its activity showed a pronounced decrease in the L-NAME treatment group and was increased in the atorvastatin group. Based on our findings, we concluded that the atorvastatin had HDL-related antioxidant activity as well as lipid-lowering properties. | |
dc.language.iso | eng | |
dc.subject | Tıbbi Ekoloji ve Hidroklimatoloji | |
dc.subject | Dahili Tıp Bilimleri | |
dc.subject | Sağlık Bilimleri | |
dc.subject | Tıp | |
dc.subject | Klinik Tıp (MED) | |
dc.subject | Klinik Tıp | |
dc.subject | TIP, ARAŞTIRMA VE DENEYSEL | |
dc.title | The effects of atorvastatin on oxidative stress in L-NAME-treated rats | |
dc.type | Makale | |
dc.relation.journal | SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION | |
dc.contributor.department | Yıldız Teknik Üniversitesi , Fen-Edebiyat Fakültesi , Kimya Bölümü | |
dc.identifier.volume | 73 | |
dc.identifier.issue | 7 | |
dc.identifier.startpage | 591 | |
dc.identifier.endpage | 597 | |
dc.contributor.firstauthorID | 18551 | |