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dc.contributor.authorErkan, Melike
dc.contributor.authorYildizbayrak, Nebahat
dc.date.accessioned2021-03-05T13:40:59Z
dc.date.available2021-03-05T13:40:59Z
dc.date.issued2019
dc.identifier.citationYildizbayrak N., Erkan M., "Therapeutic effect of curcumin on acrylamide-induced apoptosis mediated by MAPK signaling pathway in Leydig cells", JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, cilt.33, 2019
dc.identifier.issn1095-6670
dc.identifier.otherav_b35c008a-0198-4cb2-9dd1-ca95aad82fbc
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/119466
dc.identifier.urihttps://doi.org/10.1002/jbt.22326
dc.description.abstractThe aim of this study was to investigate the possible therapeutic effects of curcumin (CUR), against acrylamide (AA)-induced toxic effects on Leydig cells. The AA and CUR-treated cells were evaluated for cell viability, lipid peroxidation, reactive oxygen species (hydroxyl radical and hydrogen peroxide), antioxidant levels (glutathione peroxidase, glutathione-S-transferase, and catalase), apoptosis/necrosis rates and phosphorylation status of mitogen-activated protein kinases (MAPKs). Leydig cells were exposed to four concentrations of AA (1, 10, 100, 1000 mu M) in the presence and absence of CUR (2.5 mu M) for 24 hours. According to the present result, AA concentration-dependently, increased the oxidative stress parameters and suppressed the antioxidant enzyme levels, meanwhile induced apoptosis and activated the phosphorylation of extracellular signal-regulated kinase, p38, and c-Jun NH2-terminal kinase. Moreover, CUR ameliorated the detrimental effects of AA. Thus, AA-induced apoptosis through activation of the MAPK signaling pathway and CUR has a protective effect against AA-induced damage in Leydig cells.
dc.language.isoeng
dc.subjectFarmasötik Toksikoloji
dc.subjectYaşam Bilimleri
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectSitogenetik
dc.subjectTemel Bilimler
dc.subjectEczacılık
dc.subjectMeslek Bilimleri
dc.subjectSağlık Bilimleri
dc.subjectFarmakoloji ve Toksikoloji
dc.subjectTOKSİKOLOJİ
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectBİYOKİMYA VE MOLEKÜLER BİYOLOJİ
dc.titleTherapeutic effect of curcumin on acrylamide-induced apoptosis mediated by MAPK signaling pathway in Leydig cells
dc.typeMakale
dc.relation.journalJOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
dc.contributor.departmentİstanbul Üniversitesi , ,
dc.identifier.volume33
dc.identifier.issue7
dc.contributor.firstauthorID36494


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