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dc.contributor.authorIsbilen, Elif
dc.contributor.authorDasdemir, Selcuk
dc.contributor.authorIsbir, Turgay
dc.contributor.authorBekpinar, Seldag
dc.contributor.authorCakmakoglu, Bedia
dc.contributor.authorGurdol, Figen
dc.date.accessioned2021-03-05T13:41:05Z
dc.date.available2021-03-05T13:41:05Z
dc.date.issued2012
dc.identifier.citationGurdol F., Cakmakoglu B., Dasdemir S., Isbilen E., Bekpinar S., Isbir T., "-765 G -> C and -1195 A -> G Promoter Variants of the Cyclooxygenase-2 Gene Decrease the Risk for Preeclampsia", GENETIC TESTING AND MOLECULAR BIOMARKERS, cilt.16, ss.435-438, 2012
dc.identifier.issn1945-0265
dc.identifier.othervv_1032021
dc.identifier.otherav_b35f5b2c-e99b-4f71-8bee-f9c833870d4c
dc.identifier.urihttp://hdl.handle.net/20.500.12627/119472
dc.identifier.urihttps://doi.org/10.1089/gtmb.2011.0178
dc.description.abstractCyclooxygenase-2 (COX-2) is the inducible isoenzyme of COX that leads to increased production of prostaglandins and thromboxane, the mediators of inflammation. Controversial data regarding COX levels or activities in the placentas of women with preeclampsia have led us to examine whether a single nucleotide polymorphism (SNP) in the COX-2 gene is associated with the onset of preeclampsia. Two polymorphisms in the promoter region of COX-2 gene were examined by the polymerase chain reaction and restriction fragment length polymorphism in 128 controls and 74 preeclamptic patients. Genotype distribution and allelic frequencies for -765G -> C polymorphism of COX-2 gene were significantly different between patients and controls (p = 0.000 and p = 0.042, respectively). The odds ratio (OR) for preeclampsia risk associated to the -765G allelic variant was 4.07 (95% confidence interval [CI]: 0.89-18.56). The AA genotype of the -1195 A -> G variant was present at a significantly higher frequency among all preeclamptic subjects (p = 0.000 chi(2) : 13.4, OR: 3.44, 95% CI: 1.74-6.77). A moderate linkage was observed between the -765G and -1195A variants (D-0 : 0.201; r(2) : 0.003). These findings suggest that SNPs, -765G -> C and -1195 A -> G, on the promoter region of COX-2 gene may reduce the risk of preeclampsia, possibly by affecting the rate of gene expression.
dc.language.isoeng
dc.subjectYaşam Bilimleri
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectSitogenetik
dc.subjectTemel Bilimler
dc.subjectDahili Tıp Bilimleri
dc.subjectTıbbi Genetik
dc.subjectSağlık Bilimleri
dc.subjectTıp
dc.subjectGENETİK VE HAYAT
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectBİYOKİMYA VE MOLEKÜLER BİYOLOJİ
dc.title-765 G -> C and -1195 A -> G Promoter Variants of the Cyclooxygenase-2 Gene Decrease the Risk for Preeclampsia
dc.typeMakale
dc.relation.journalGENETIC TESTING AND MOLECULAR BIOMARKERS
dc.contributor.departmentİstanbul Üniversitesi , ,
dc.identifier.volume16
dc.identifier.issue5
dc.identifier.startpage435
dc.identifier.endpage438
dc.contributor.firstauthorID29774


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