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Reduced muscle mitochondrial enzyme activity in MuSK-immunized mice.

dc.contributor.authorYetimler, Berrak
dc.contributor.authorOzkok, Elif
dc.contributor.authorTasli, Hatice
dc.contributor.authorDurmus, Hacer
dc.contributor.authorUlusoy, Canan Aysel
dc.contributor.authorTRAKAS, Nikolaos
dc.contributor.authorLagoumintzis, George
dc.contributor.authorTZARTOS, Socrates
dc.contributor.authorTuzun, Erdem
dc.date.accessioned2021-03-05T13:51:21Z
dc.date.available2021-03-05T13:51:21Z
dc.date.issued2015
dc.identifier.citationOzkok E., Durmus H., Yetimler B., Tasli H., TRAKAS N., Ulusoy C. A. , Lagoumintzis G., TZARTOS S., Tuzun E., "Reduced muscle mitochondrial enzyme activity in MuSK-immunized mice.", Clinical neuropathology, cilt.34, ss.359-63, 2015
dc.identifier.issn0722-5091
dc.identifier.othervv_1032021
dc.identifier.otherav_b4392de9-ccad-4a5e-a28e-d7737a258232
dc.identifier.urihttp://hdl.handle.net/20.500.12627/120026
dc.identifier.urihttps://doi.org/10.5414/np300875
dc.description.abstractAim: Muscle specific kinase (MuSK) antibody-positive myasthenia gravis (MG) patients might present with clinical and electrophysiological signs of muscle atrophy. In this study, we investigated the potential contribution of mitochondrial dysfunction to muscle atrophy induced by MuSK immunity. Methods: Mitochondrial enzyme expression was investigated in muscle samples of MuSK-immunized, acetylcholine receptor (AChR)-immunized, and complete Freund's adjuvant (CFA)-immunized C57BL/6 (B6) mice using histochemical methods. Mitochondrial enzyme activity was also investigated in MuSK- and CFA-immunized mice. Results: Histochemical analysis showed normal muscle fiber activity on succinate dehydrogenase (SDH) and cytochrome oxidase (COX) stains in all immunization groups. However, MuSK-immunized mice had more ragged-red fibers on modified Gomori-trichrome (MGT) stain and more pronounced type 1 muscle fiber atrophy. MuSK-immunized mice also showed reduced citrate synthase, SDH, and NADH-cytochrome c-reductase activity. Discussion: Our results suggest that MuSK-immunity might induce muscle atrophy through mitochondrial dysfunction.
dc.language.isoeng
dc.subjectTemel Tıp Bilimleri
dc.subjectBiyokimya
dc.subjectDahili Tıp Bilimleri
dc.subjectNöroloji
dc.subjectCerrahi Tıp Bilimleri
dc.subjectPatoloji
dc.subjectYaşam Bilimleri
dc.subjectTemel Bilimler
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectBiyoloji ve Biyokimya
dc.subjectPATOLOJİ
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectKLİNİK NEUROLOJİ
dc.titleReduced muscle mitochondrial enzyme activity in MuSK-immunized mice.
dc.typeMakale
dc.relation.journalClinical neuropathology
dc.contributor.departmentHellenic Pasteur Inst , ,
dc.identifier.volume34
dc.identifier.issue6
dc.identifier.startpage359
dc.identifier.endpage63
dc.contributor.firstauthorID2325


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