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dc.contributor.authorFeld, J. J.
dc.contributor.authorCalinas, F.
dc.contributor.authorGschwantler, M.
dc.contributor.authorGane, E.
dc.contributor.authorCrawford, D.
dc.contributor.authorJacobson, I. M.
dc.contributor.authorDumas, E. O.
dc.contributor.authorKing, M.
dc.contributor.authorSulkowski, M.
dc.contributor.authorOzaras, R.
dc.contributor.authorAlqahtani, S.
dc.contributor.authorIsakov, V.
dc.contributor.authorWyles, D.
dc.contributor.authorFerenci, P.
dc.date.accessioned2021-03-05T14:09:47Z
dc.date.available2021-03-05T14:09:47Z
dc.date.issued2017
dc.identifier.citationAlqahtani S., Ozaras R., Isakov V., Wyles D., Ferenci P., Feld J. J. , Calinas F., Gschwantler M., Gane E., Crawford D., et al., "Time to viral suppression is not related to achievement of SVR12 in HCV GT1-infected patients treated with ombitasvir/paritaprevir/ritonavir and dasabuvir with or without ribavirin", JOURNAL OF VIRAL HEPATITIS, cilt.24, ss.280-286, 2017
dc.identifier.issn1352-0504
dc.identifier.otherav_b5c75381-7286-431d-8316-16fea29c1454
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/120997
dc.identifier.urihttps://doi.org/10.1111/jvh.12641
dc.description.abstractHigh rates of sustained virologic response at post-treatment week 12 (SVR12) were achieved in six phase 3 trials of ombitasvir (OBV, an NS5A inhibitor), paritaprevir (an NS3/4A protease inhibitor) co-dosed with ritonavir (PTV/r) + dasabuvir (DSV, an NS5B RNA polymerase inhibitor) (ie, 3D regimen) with or without ribavirin (RBV) in adults with chronic genotype (GT) 1 hepatitis C virus (HCV) infection. We assessed whether time to first HCV RNA value below the lower limit of quantification in patients with and without cirrhosis was associated with achievement of SVR12. Data were analysed from GT1-infected patients enrolled in six phase 3 studies of 3D +/- RBV. Patients who experienced non-virologic failure were excluded from analysis. HCV RNA was determined using the Roche COBAS TaqMan RT-PCR assay (lower limit of quantification, LLOQ =25 IU/mL). SVR12 was analysed by week of first HCV RNA suppression, defined as HCV RNA <LLOQ. The analysis included a total of 2027 patients. Cumulative proportions of subjects with initial HCV RNA suppression <LLOQ at weeks 1, 2, 4 and 6 were 31%, 81%, 99% and 100%, respectively. SVR12 was achieved by 98%, 97%, 98% and 92% of patients with initial suppression at Weeks 1, 2, 4 and 6, respectively (P=.42, trend test). Across six phase 3 trials of 3D +/- RBV, most patients achieved viral suppression by week 2. Time to viral suppression was not associated with subsequent achievement of SVR12, suggesting that on-treatment virologic monitoring may not be necessary with this regimen.
dc.language.isoeng
dc.subjectİç Hastalıkları
dc.subjectGASTROENTEROLOJİ VE HEPATOLOJİ
dc.subjectKlinik Tıp
dc.subjectKlinik Tıp (MED)
dc.subjectBULAŞICI HASTALIKLAR
dc.subjectİmmünoloji
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectVİROLOJİ
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectTemel Tıp Bilimleri
dc.subjectMikrobiyoloji ve Klinik Mikrobiyoloji
dc.subjectViroloji
dc.subjectDahili Tıp Bilimleri
dc.subjectGastroenteroloji-(Hepatoloji)
dc.subjectYaşam Bilimleri
dc.subjectTemel Bilimler
dc.titleTime to viral suppression is not related to achievement of SVR12 in HCV GT1-infected patients treated with ombitasvir/paritaprevir/ritonavir and dasabuvir with or without ribavirin
dc.typeMakale
dc.relation.journalJOURNAL OF VIRAL HEPATITIS
dc.contributor.departmentJohns Hopkins University , ,
dc.identifier.volume24
dc.identifier.issue4
dc.identifier.startpage280
dc.identifier.endpage286
dc.contributor.firstauthorID242083


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