Evaluation of maternal serum hypoxia inducible factor-1α, progranulin and syndecan-1 levels in pregnancies with early- and late-onset preeclampsia
Tarih
2018Yazar
Davutoglu, Ebru
Yilmaz, Nevin
Firat, Asuman Akkaya
Uzun, Isil
Yuksel, Ilkbal Temel
Ozel, Aysegul
Madazli, Riza
Üst veri
Tüm öğe kaydını gösterÖzet
© 2017 Informa UK Limited, trading as Taylor & Francis Group.Objective: To determine the serum levels of HIF-1 α, progranulin, and syndecan-1 in preeclampsia (PE) and normal pregnancy, and to compare whether these markers demonstrate any difference between early-onset PE (EO-PE) and late-onset PE (LO-PE). Methods: This cross-sectional study was conducted on 27 women with EO-PE, 27 women with LO-PE, and 26 healthy normotensive pregnant controls matched for gestational age. Maternal levels of serum HIF-1 α, progranulin, and syndecan-1 were measured with the use of an enzyme-linked immunosorbent assay kit. Results: Statistical analysis revealed significant differences between the control and the PE groups in progranulin (p <.001) and syndecan-1 (p <.001) levels. There were no significant differences in the serum HIF-1 α levels between these groups (p=.069). When PE patients were evaluated by considering subgroups; statistical analysis revealed significant inter-group differences in all biomarkers. Serum progranulin levels were significantly higher in LO-PE compared with the other two groups (EO-PE versus LO-PE and LO-PE versus controls p =.000). Control group presented significantly higher syndecan-1 levels, than EO and LO-PE (p <.001). HIF-1 α levels positively correlated with progranulin levels (r =.439, p=.000). Conclusions: Serum progranulin may have potential to be used as a biomarker for the differentiation of EO-PE and LO-PE. The co-operative action between HIF-1 α and progranulin might play a key role in the pathogenesis of LO-PE. The predominant feature of LO-PE seems to be an inflammatory process, whereas in EO-PE placentation problem seems to be the main pathology.
Bağlantı
http://hdl.handle.net/20.500.12627/121179https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85020231270&origin=inward
https://doi.org/10.1080/14767058.2017.1333098
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