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dc.contributor.authorAdelsberger, PA
dc.contributor.authorBASARAN, Seher
dc.contributor.authorBinkert, F
dc.contributor.authorAntonarakis, SA
dc.contributor.authorSchinzel, A
dc.date.accessioned2021-03-05T14:59:58Z
dc.date.available2021-03-05T14:59:58Z
dc.date.issued1992
dc.identifier.citationSchinzel A., Adelsberger P., Binkert F., BASARAN S., Antonarakis S., "NO EVIDENCE FOR A PATERNAL INTERCHROMOSOMAL EFFECT FROM ANALYSIS OF THE ORIGIN OF NONDISJUNCTION IN DOWN-SYNDROME PATIENTS WITH CONCOMITANT FAMILIAL CHROMOSOME REARRANGEMENTS", AMERICAN JOURNAL OF HUMAN GENETICS, cilt.50, ss.288-293, 1992
dc.identifier.issn0002-9297
dc.identifier.othervv_1032021
dc.identifier.otherav_b9daa691-58a1-439d-991e-bf9bbad6dbd2
dc.identifier.urihttp://hdl.handle.net/20.500.12627/123635
dc.description.abstractThe parental origin of the extra chromosome 21 was determined with DNA polymorphisms in seven families in whom the proband and one of the parents carried an additional chromosome rearrangement (balanced translocation or pericentric inversion) not involving chromosome 21. The balanced rearrangement was inherited from the mother in two families and from the father in five families, whereas the additional chromosome 21 was derived from the mother in all seven families. These findings are not in agreement with the hypothesis of a paternal interchromosomal effect. The latter would imply that a balanced rearrangement in the father would favor nondisjunction during meiosis in the germ cells.
dc.language.isoeng
dc.subjectYaşam Bilimleri
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectTemel Bilimler
dc.subjectDahili Tıp Bilimleri
dc.subjectTıbbi Genetik
dc.subjectSağlık Bilimleri
dc.subjectTıp
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectGENETİK VE HAYAT
dc.titleNO EVIDENCE FOR A PATERNAL INTERCHROMOSOMAL EFFECT FROM ANALYSIS OF THE ORIGIN OF NONDISJUNCTION IN DOWN-SYNDROME PATIENTS WITH CONCOMITANT FAMILIAL CHROMOSOME REARRANGEMENTS
dc.typeMakale
dc.relation.journalAMERICAN JOURNAL OF HUMAN GENETICS
dc.contributor.department, ,
dc.identifier.volume50
dc.identifier.issue2
dc.identifier.startpage288
dc.identifier.endpage293
dc.contributor.firstauthorID12732


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