Dental follicle mesenchymal stem cell administration ameliorates muscle weakness in MuSK-immunized mice.

Author
Ulusoy, Canan Aysel
Tasli, Hatice
Akkoc, Tunc
Kucukerden, Melike
Tuzun, Erdem
Zibandeh, Noushin
Yildirim, Selin
TRAKAS, Nikolaos
ZISIMOPOULOU, Paraskevi
TZARTOS, Socrates
Goker, Kamil
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Abstract
Background: Myasthenia gravis (MG) is an antibody-mediated autoimmune disease of the neuromuscular junction (NMJ), mostly associated with acetylcholine receptor (AChR) antibodies. Around 5-10 % of MG patients show antibodies to muscle-specific tyrosine kinase (MuSK). Mesenchymal stem cell (MSC) administration has been shown to ameliorate muscle weakness in the experimental autoimmune myasthenia gravis (EAMG) model induced by AChR immunization.
URI
http://hdl.handle.net/20.500.12627/123641
https://doi.org/10.1186/s12974-015-0451-0
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