dc.contributor.author | Cinar, F | |
dc.contributor.author | Gurdol, F | |
dc.contributor.author | Kocak, H | |
dc.contributor.author | Oner, P | |
dc.date.accessioned | 2021-03-02T22:03:22Z | |
dc.date.available | 2021-03-02T22:03:22Z | |
dc.date.issued | 2002 | |
dc.identifier.citation | Oner P., Cinar F., Kocak H., Gurdol F., "Effect of exogenous melatonin on ethanol-induced changes in Na+,K+- and Ca2+-ATPase activities in rat synaptosomes", NEUROCHEMICAL RESEARCH, cilt.27, sa.12, ss.1619-1623, 2002 | |
dc.identifier.issn | 0364-3190 | |
dc.identifier.other | av_0a75e176-66eb-46eb-b4d6-54f868c95c6c | |
dc.identifier.other | vv_1032021 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/12779 | |
dc.identifier.uri | https://doi.org/10.1023/a:1021678809464 | |
dc.description.abstract | In the present study, the effects of acute ethanol ( EtOH) toxicity and of exogenous melatonin (MLT) on this toxicity were examined by measuring membrane-bound ATPases and acetylcholinesterase activities in rat synaptosomal membranes. The concentrations of plasma alpha-tocopherol and adrenal ascorbic acid (AA) were also measured. Synaptosomal Na+, K+- ATPase and Ca2+-ATPase activities were significantly depressed in acute EtOH-intoxicated rats compared with controls, while acetylcholinesterase activity remained unaltered. Pretreatment with MLT (10 mg/kg) prior to acute EtOH administration prevented EtOH-induced inhibition of ATPases. Adrenal AA and plasma alpha-tocopherol levels were also depressed regardless of MLT pretreatment. MLT treatment alone affected neither membrane-bound enzyme activities nor tissue and blood levels of vitamins C and E. It is concluded that acute EtOH intoxication disturbs neural transport functions through the membrane-bound ATPase activity depression. Reduced AA and alpha-tocopherol levels may contribute to the neurodegenerative effects of EtOH. However, pretreatment with a high dose of MLT before EtOH administration may be beneficial to prevent EtOH-induced toxicity on ATPase-mediated neural transport functions. | |
dc.language.iso | eng | |
dc.subject | Temel Bilimler | |
dc.subject | Sinirbilim ve Davranış | |
dc.subject | Sitogenetik | |
dc.subject | Yaşam Bilimleri | |
dc.subject | Moleküler Biyoloji ve Genetik | |
dc.subject | NEUROSCIENCES | |
dc.subject | Yaşam Bilimleri (LIFE) | |
dc.subject | Moleküler Biyoloji ve Genetik | |
dc.subject | BİYOKİMYA VE MOLEKÜLER BİYOLOJİ | |
dc.title | Effect of exogenous melatonin on ethanol-induced changes in Na+,K+- and Ca2+-ATPase activities in rat synaptosomes | |
dc.type | Makale | |
dc.relation.journal | NEUROCHEMICAL RESEARCH | |
dc.contributor.department | , , | |
dc.identifier.volume | 27 | |
dc.identifier.issue | 12 | |
dc.identifier.startpage | 1619 | |
dc.identifier.endpage | 1623 | |
dc.contributor.firstauthorID | 166565 | |