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dc.contributor.authorOzkul, Ayse Ayaz
dc.contributor.authorKarsidag, Kubilay
dc.contributor.authorElevli, Murat
dc.contributor.authorKara, Pinar Gizem
dc.contributor.authorDogru, Macit
dc.contributor.authorAltinli, Sebnem
dc.date.accessioned2021-03-05T16:25:21Z
dc.date.available2021-03-05T16:25:21Z
dc.date.issued2007
dc.identifier.citationAltinli S., Elevli M., Ozkul A. A. , Kara P. G. , Karsidag K., Dogru M., "Insulin resistance and metabolic syndrome in children of parents with diabetes mellitus", JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM, cilt.20, ss.431-436, 2007
dc.identifier.issn0334-018X
dc.identifier.othervv_1032021
dc.identifier.otherav_c08448d0-8ad8-4876-a501-ddf7abd0217b
dc.identifier.urihttp://hdl.handle.net/20.500.12627/127803
dc.identifier.urihttps://doi.org/10.1515/jpem.2007.20.3.431
dc.description.abstractThe aim of this prospective study was to research features of insulin resistance and metabolic syndrome in offspring of diabetic parents and to rind out whether there is a risk of developing type 2 diabetes mellitus (DM) in these children. Study participants were 30 children of parents with type I DM (DMI) (Group I) and I I children of parents with type 2 DM (DM2) (Group II) who were being followed up in the Diabetes Department of Haseki Research and Training Hospital. The results were compared with a control group of 17 children in the same age group (Group III). There were no statistically significant differences between the Group I and the control group in fasting blood glucose, oral glucose tolerance test values, 1(st) and 2(nd) hour insulin, homeostasis model assessment (HOMA) values, body mass index (BMI), systolic and diastolic blood pressure, and lipid parameters, i.e. HDL-cholesterol, LDLcholesterol, VLDL-cholesterol, total cholesterol, and triglycerides. Fasting, 1(st) and 2(nd) hour blood insulin levels, HOMA values, BMI, and systolic blood pressure values were significantly higher in Group II compared to the control group (p < 0.05). There were no statistically significant differences between Group II and the control group in lipid parameters, fasting blood glucose, OGTT values, or diastolic blood pressure. We conclude that in our population there is a tendency of insulin resistance and metabolic syndrome in the offspring of parents with DM2, and a risk for developing DM2. Thus, children of patients with DM2 should be followed up so as to recognize early metabolic defects of glucose metabolism and to plan effective preventive efforts to reduce cardiovascular and atherosclerotic risk factors.
dc.language.isoeng
dc.subjectİç Hastalıkları
dc.subjectEndokrinoloji ve Metabolizma Hastalıkları
dc.subjectSağlık Bilimleri
dc.subjectÇocuk Sağlığı ve Hastalıkları
dc.subjectDahili Tıp Bilimleri
dc.subjectTıp
dc.subjectPEDİATRİ
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectENDOKRİNOLOJİ VE METABOLİZMA
dc.titleInsulin resistance and metabolic syndrome in children of parents with diabetes mellitus
dc.typeMakale
dc.relation.journalJOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
dc.contributor.department, ,
dc.identifier.volume20
dc.identifier.issue3
dc.identifier.startpage431
dc.identifier.endpage436
dc.contributor.firstauthorID182098


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