dc.contributor.author | Cihan-Ustundag, Gökçe | |
dc.contributor.author | Capan, Gultaze | |
dc.date.accessioned | 2021-03-05T16:39:56Z | |
dc.date.available | 2021-03-05T16:39:56Z | |
dc.date.issued | 2012 | |
dc.identifier.citation | Cihan-Ustundag G., Capan G., "Synthesis and evaluation of functionalized indoles as antimycobacterial and anticancer agents", MOLECULAR DIVERSITY, cilt.16, ss.525-539, 2012 | |
dc.identifier.issn | 1381-1991 | |
dc.identifier.other | av_c1b9c0bd-96e6-4b32-899c-fc518422cd99 | |
dc.identifier.other | vv_1032021 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/128575 | |
dc.identifier.uri | https://doi.org/10.1007/s11030-012-9385-y | |
dc.description.abstract | A new series of 5-fluoro-N-2-(cyclohexylidene)-3-phenyl-1H-indole-2-carbohydrazides (6a-6e) and their cyclization products 5-fluoro-N-(3-oxo-1-thia-4-azaspiro [4.5]dec-4-yl)-3-phenyl-1H-indole-2-carboxamides (7a-7e, 8a-8e) have been synthesized and evaluated for in vitro antimycobacterial activity against Mycobacterium tuberculosis H37Rv using the Microplate Alamar Blue Assay (MABA). Compounds showed moderate to good inhibitory activity at 6.25 mu g/mL. Among them, 7b, 7d, 8b, and 8d were the most potent analogs with an inhibition range of 91-95 %. Additionally, compounds 6a, 7a, 7e, 8a, and 8e were subjected to the National Cancer Institute's (NCI) in vitro disease-oriented antitumor screening to be evaluated for antitumor activity. 8e, the most potent compound examined, displayed broad spectrum antiproliferative activity with particular selectivity against four leukemia cell lines (CCRF-CEM, HL-60 (TB), K-562, and RPMI-8226) with log (10) GI (50) values between -5.68 and -6.09. | |
dc.language.iso | eng | |
dc.subject | Sağlık Bilimleri | |
dc.subject | BİYOKİMYA VE MOLEKÜLER BİYOLOJİ | |
dc.subject | Moleküler Biyoloji ve Genetik | |
dc.subject | Yaşam Bilimleri (LIFE) | |
dc.subject | Eczacılık | |
dc.subject | Temel Eczacılık Bilimleri | |
dc.subject | Yaşam Bilimleri | |
dc.subject | Moleküler Biyoloji ve Genetik | |
dc.subject | Sitogenetik | |
dc.subject | Biyokimya | |
dc.subject | Alkoloidler | |
dc.subject | Diğer | |
dc.subject | Temel Bilimler | |
dc.subject | KİMYA, UYGULAMALI | |
dc.subject | Kimya | |
dc.subject | Temel Bilimler (SCI) | |
dc.subject | KİMYA, TIP | |
dc.subject | KİMYA, MULTİDİSİPLİNER | |
dc.subject | FARMAKOLOJİ VE ECZACILIK | |
dc.subject | Farmakoloji ve Toksikoloji | |
dc.title | Synthesis and evaluation of functionalized indoles as antimycobacterial and anticancer agents | |
dc.type | Makale | |
dc.relation.journal | MOLECULAR DIVERSITY | |
dc.contributor.department | İstanbul Üniversitesi , , | |
dc.identifier.volume | 16 | |
dc.identifier.issue | 3 | |
dc.identifier.startpage | 525 | |
dc.identifier.endpage | 539 | |
dc.contributor.firstauthorID | 4929 | |