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dc.contributor.authorYanardag, Refiye
dc.contributor.authorSacan, Ozlem
dc.contributor.authorBolkent, Sema
dc.contributor.authorBolkent, Sehnaz
dc.date.accessioned2021-03-05T16:57:54Z
dc.date.available2021-03-05T16:57:54Z
dc.date.issued2008
dc.identifier.citationBolkent S., Sacan O., Yanardag R., Bolkent S., "Effects of vitamin E, vitamin C, and selenium on gastric fundus in cadmium toxicity in male rats", INTERNATIONAL JOURNAL OF TOXICOLOGY, cilt.27, ss.217-222, 2008
dc.identifier.issn1091-5818
dc.identifier.othervv_1032021
dc.identifier.otherav_c32a2b8d-f13c-4609-ad14-c5c8731cbfe0
dc.identifier.urihttp://hdl.handle.net/20.500.12627/129510
dc.identifier.urihttps://doi.org/10.1080/10915810801992384
dc.description.abstractCadmium (Cd) is a highly toxic metal. It has an indirect role in the generation of various free radicals. Antioxidants such as vitamin E, vitamin C, and selenium are important for preventing the damage caused by reactive oxygen species. This study was undertaken to examine the effect of acute cadmium and/or antioxidants on serum lipid metabolism, tissue glutathione, and lipid peroxidation (LPO) levels, and ghrelin and metallothionein production in the gastric fundus mucosa of rats. Cd (2 mg/kg/day CdCl2) was administered to rats for 8 days, intraperitoneally. Vitamin E (250 mg /kg/day) + vitamin C (250 mg/kg/day) + sodium selenate (0.25 mg /kg/day) were administered to rats orally at the same time. The animals were treated by antioxidants 1 h prior to treatment with Cd every day. Gastric tissue homogenates were used for protein and glutathione and LPO levels. Phospholipid and total lipid levels were determined in serum. Gastric fundus sections examined for histopathological changes and by immunohistochemistry for expression of ghrelin and metallothionein. In the group treated with Cd, degenerative changes such as discontinuity in the surface epithelium were observed. The degenerative changes induced by Cd were decreased in the group given vitamin E + vitamin C + selenium. There was no significant change in ghrelin-and metallothionein-immunoreactive cells in fundus mucosa. Stomach glutathione levels insignificantly decreased in the Cd groups, but in the Cd group given antioxidant, stomach glutathione levels were significantly increased. Serum phospholipid and total lipid levels were significantly increased in the Cd groups. On the other hand, treatment with antioxidants reversed these effects. These results indicate that antioxidants partly prevent the toxicity of Cd in rat gastric fundus.
dc.language.isoeng
dc.subjectFarmasötik Toksikoloji
dc.subjectYaşam Bilimleri
dc.subjectTemel Bilimler
dc.subjectEczacılık
dc.subjectMeslek Bilimleri
dc.subjectTemel Eczacılık Bilimleri
dc.subjectSağlık Bilimleri
dc.subjectTOKSİKOLOJİ
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectFarmakoloji ve Toksikoloji
dc.subjectFARMAKOLOJİ VE ECZACILIK
dc.titleEffects of vitamin E, vitamin C, and selenium on gastric fundus in cadmium toxicity in male rats
dc.typeMakale
dc.relation.journalINTERNATIONAL JOURNAL OF TOXICOLOGY
dc.contributor.department, ,
dc.identifier.volume27
dc.identifier.issue2
dc.identifier.startpage217
dc.identifier.endpage222
dc.contributor.firstauthorID185896


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