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Dual Akt and Bcl-2 inhibition induces cell-type specific modulation of apoptotic and autophagic signaling in castration resistant prostate cancer cell lines
(2021)
Background Cancer cell survival depends on the cross-regulation between apoptosis and autophagy which share common signaling pathways including PI3K/Akt/mTOR and Bcl-2. The aim of this study was to elucidate the modulation ...
Oyun Mekânlarında Mekânı Tanımlayan Öğelerin Boyuta Bağlı Değişimi: It Takes Two Örneği
(2022)
Mekânın anlamlandırılabilmesi ve tanımlanabilmesi için kullanıcıların içinde bulundukları ve etkileşim halinde oldukları mekânları duyuları, bilgi ve tecrübelerinden faydalanarak algılaması gerekmektedir. Mekânın tanımlanması ...
A Novel nonsense variant in the CDH2 gene associated with ACOGS: A case report
Agenesis of Corpus Callosum, Cardiac, Ocular, and Genital Syndrome (ACOGS; OMIM #618929) is a rare genetic disorder characterized by global developmental delay, agenesis or hypoplasia of corpus callosum, craniofacial ...
Global Differences in Risk Factors, Etiology, and Outcome of Ischemic Stroke in Young Adults-A Worldwide Meta-analysis The GOAL Initiative
(2022)
Background and Objectives There is a worldwide increase in the incidence of stroke in young adults, with major regional and ethnic differences. Advancing knowledge of ethnic and regional variation in causes and outcomes ...