dc.contributor.author | Seker, F. Burcu | |
dc.contributor.author | Kaptan, Engin | |
dc.contributor.author | Oztas, Baria | |
dc.contributor.author | Yorulmaz, Hatice | |
dc.date.accessioned | 2021-03-02T22:06:34Z | |
dc.date.available | 2021-03-02T22:06:34Z | |
dc.date.issued | 2015 | |
dc.identifier.citation | Yorulmaz H., Kaptan E., Seker F. B. , Oztas B., "Type 1 diabetes exacerbates blood-brain barrier alterations during experimental epileptic seizures in an animal model", CELL BIOCHEMISTRY AND FUNCTION, cilt.33, sa.5, ss.285-292, 2015 | |
dc.identifier.issn | 0263-6484 | |
dc.identifier.other | av_0ac86fac-75d9-422c-8b8f-8621268905b1 | |
dc.identifier.other | vv_1032021 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/12964 | |
dc.identifier.uri | https://doi.org/10.1002/cbf.3113 | |
dc.description.abstract | The aim of this study was to perform the effects of diabetes on the permeability of the blood-brain barrier (BBB) during pentylenetetrazole (PTZ)-induced epileptic attacks. For this propose, the animals were divided into four groups. These groups contained were intact, PTZ-treated, diabetic and PTZ-treated diabetic individuals, respectively. To evaluate the functioning of the BBB, Evans blue was used as a BBB permeability indicator, and the expressions of zonula occludens-1 and glial fibrillary acidic protein involving the functioning of the BBB were determined immunohistochemically. Also, the changes in the release of serum tumour necrosis factor-alpha and interleukin-10 and interleukin-12 were studied by using enzyme-linked immunosorbent assay method. BBB permeability in the seizures under diabetic conditions showed a considerable increase (p<001) in all of the brain we studied. The immunoreactive staining intensity of zonula occludens-1 and glial fibrillary acidic protein was found reduced in the brain regions of diabetic rats (p<001). However, the serum level of tumour necrosis factor-alpha increased in diabetes and diabetes+PTZ groups, and the serum level of interleukin-12 increased significantly in all experimental groups (p<005). In conclusion, diabetes dramatically increases BBB damage during epileptic seizures, and it may be derived from an elevation of paracellular passage. Copyright (c) 2015 John Wiley & Sons, Ltd. | |
dc.language.iso | eng | |
dc.subject | Yaşam Bilimleri | |
dc.subject | Moleküler Biyoloji ve Genetik | |
dc.subject | Sitogenetik | |
dc.subject | Temel Bilimler | |
dc.subject | Temel Tıp Bilimleri | |
dc.subject | Histoloji-Embriyoloji | |
dc.subject | Sağlık Bilimleri | |
dc.subject | Tıp | |
dc.subject | HÜCRE BİYOLOJİSİ | |
dc.subject | Yaşam Bilimleri (LIFE) | |
dc.subject | Moleküler Biyoloji ve Genetik | |
dc.subject | BİYOKİMYA VE MOLEKÜLER BİYOLOJİ | |
dc.title | Type 1 diabetes exacerbates blood-brain barrier alterations during experimental epileptic seizures in an animal model | |
dc.type | Makale | |
dc.relation.journal | CELL BIOCHEMISTRY AND FUNCTION | |
dc.contributor.department | Haliç Üniversitesi , , | |
dc.identifier.volume | 33 | |
dc.identifier.issue | 5 | |
dc.identifier.startpage | 285 | |
dc.identifier.endpage | 292 | |
dc.contributor.firstauthorID | 223227 | |