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dc.contributor.authorAslan, Serap
dc.contributor.authorNEŞETOĞLU, Neşet
dc.contributor.authorUnal, Duri Şehvar
dc.contributor.authorKaplan, Cem
dc.date.accessioned2021-03-05T17:50:02Z
dc.date.available2021-03-05T17:50:02Z
dc.date.issued2020
dc.identifier.citationNEŞETOĞLU N., Kaplan C., Aslan S., Unal D. Ş. , "A Simple and Rapid LC-MS/MS Method for Therapeutic Drug Monitoring of Lenalidomide", PAKISTAN JOURNAL OF ANALYTICAL & ENVIRONMENTAL CHEMISTRY, cilt.21, ss.19-26, 2020
dc.identifier.othervv_1032021
dc.identifier.otherav_c7742510-168c-4b4d-b12d-0d723f6bbd87
dc.identifier.urihttp://hdl.handle.net/20.500.12627/132212
dc.identifier.urihttps://doi.org/10.21743/pjaec/2020.06.03
dc.description.abstractImmunomodulatory drugs lenalidomide (LENA) and pomalidomide (POMA) are synthetic compounds derived by modifying the chemical structure of thalidomide to improve its potency and reduce its side effects. LENA is used as a treatment for myeloma and blood disorders called myelodysplastic syndromes. The maximum clinical dose of LENA for some haematological cancers is generally 213.0 for LENA and m/z 272.0 > 161.0 for POMA. The calibration curves were consistently accurate and precise over the concentration range of 20 ng/mL to 1000 ng/mL in plasma for LENA. This novel LC-MS/MS method competes with all the regulatory requirements and shows satisfactory accuracy and precision. It is sufficiently sensitive for the performance of pharmacokinetic, bioequivalence and TDM studies in humans.
dc.language.isoeng
dc.subjectKimya
dc.subjectTemel Bilimler
dc.subjectAnalitik Kimya
dc.subjectKİMYA, ANALİTİK
dc.subjectTemel Bilimler (SCI)
dc.titleA Simple and Rapid LC-MS/MS Method for Therapeutic Drug Monitoring of Lenalidomide
dc.typeMakale
dc.relation.journalPAKISTAN JOURNAL OF ANALYTICAL & ENVIRONMENTAL CHEMISTRY
dc.contributor.departmentİstanbul Üniversitesi , ,
dc.identifier.volume21
dc.identifier.issue1
dc.identifier.startpage19
dc.identifier.endpage26
dc.contributor.firstauthorID2207446


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