The effect of chronic stress on hepatic and gastric lipid peroxidation in long-term depletion of glutathione in rats

Abstract

The effect of chronic stress (immobilization and cold) on hepatic and gastric thiobarbituric acid reactive substances (TEARS) and vitamin C levels were investigated in rats having long-term depletion of glutathione (GSH) by applying buthionine sulfoximine (BSO). GSH and vitamin C levels decreased and TEARS levels increased in the liver and stomach of rats subjected to stress. Long-term BSO administration along with stress caused no additional changes in these parameters. These results may indicate that long-term glutathione depletion did not potentiate stress-induced hepatic and gastric lipid peroxidation. (C) 1997 The Italian Pharmacological Society.