dc.contributor.author | AVKAN, Vildan | |
dc.contributor.author | Vahaboglu, Haluk | |
dc.contributor.author | Dodanli, S | |
dc.contributor.author | Eroglu, Cafer | |
dc.contributor.author | Soyletir, Güner | |
dc.contributor.author | Yıldırım, İpek | |
dc.contributor.author | Ozturk, Recep | |
dc.date.accessioned | 2021-03-05T17:54:40Z | |
dc.date.available | 2021-03-05T17:54:40Z | |
dc.date.issued | 1996 | |
dc.identifier.citation | Vahaboglu H., Dodanli S., Eroglu C., Ozturk R., Soyletir G., Yıldırım İ., AVKAN V., "Characterization of multiple-antibiotic-resistant Salmonella typhimurium strains: Molecular epidemiology of PER-1-producing isolates and evidence for nosocomial plasmid exchange by a clone", JOURNAL OF CLINICAL MICROBIOLOGY, cilt.34, ss.2942-2946, 1996 | |
dc.identifier.issn | 0095-1137 | |
dc.identifier.other | av_c7d36616-f230-44e5-bb23-d19fad0450d8 | |
dc.identifier.other | vv_1032021 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/132443 | |
dc.identifier.uri | https://doi.org/10.1128/jcm.34.12.2942-2946.1996 | |
dc.description.abstract | We characterized epidemiologic and genetic features of nosocomially originated multiple-antibiotic-resistant Salmonella typhimurium isolates from two hospitals. A total of 32 multiply resistant strains, isolated during a 28-month period, were studied. Four resistance phenotypes were distinguished on the basis of the results of disc diffusion tests. Group 1 was resistant to chloramphenicol, gentamicin, tobramycin, amikacin, and the newer cephalosporins because of the production of an extended-spectrum beta-lactamase (PER-1). Group 2 exhibited the same pattern plus resistance to sulfamethoxazole-trimethoprim (Sst). Except for Sxt resistance, dominant phenotypes of both groups were transferred on an identical plasmid, pSTI1 (81 MDa). Group 3 was resistant to ampicillin, chloramphenicol, gentamicin, tobramycin, and Sxt. This pattern was also transferred on an 81-MDa plasmid (pSTI2) which differed from pSTI1 on the basis of EcoRI and HindIII restriction fragments, Group 4 was resistant to ampicillin, chloramphenicol, and tetracycline, and a 74-MDa nonconjugative plasmid was detected. Restriction fragment length polymorphism of RNA-encoding DNA and arbitrarily primed PCR tests revealed that bacteria from groups 1, 2, and 3 were clonally related. Epidemiologic data also supported the clonal-dissemination hypothesis. We conclude that S. typhimurium isolates acquire and exchange multiple-resistance plasmids in hospital microflora. | |
dc.language.iso | eng | |
dc.subject | Mikrobiyoloji | |
dc.subject | Yaşam Bilimleri (LIFE) | |
dc.subject | Yaşam Bilimleri | |
dc.subject | Temel Bilimler | |
dc.title | Characterization of multiple-antibiotic-resistant Salmonella typhimurium strains: Molecular epidemiology of PER-1-producing isolates and evidence for nosocomial plasmid exchange by a clone | |
dc.type | Makale | |
dc.relation.journal | JOURNAL OF CLINICAL MICROBIOLOGY | |
dc.contributor.department | Kocaeli Üniversitesi , , | |
dc.identifier.volume | 34 | |
dc.identifier.issue | 12 | |
dc.identifier.startpage | 2942 | |
dc.identifier.endpage | 2946 | |
dc.contributor.firstauthorID | 41640 | |