Effects of Common INSIG-2 and SCAP Gene Variants on Metabolic Parameters in Coronary Artery Disease

Abstract

The function of sterol regulator element binding proteins (SREBPs), important transcription factors in cholesterol synthesis, is associated to SREBP cleavage activating protein (SCAP), insulin induced gene product-1 (INSIG-1) and INSIG-2. In this study, the possible contribution of INSIG-2 rs9308762 and SCAP rs4858868 SNPs to CAD risk was investigated in 73 CAD patients and 58 healthy controls. The systolic and diastolic blood pressure levels of patients were higher than in the control group (P<0.001), while HDL-C levels were lower (P=0.015). In the CAD group, the observed frequency of the SCAP GA genotype was higher (P<0.05), while INSIG-2 rs9308762 genotypes and alleles were not different between study groups. The INSIG2 rare T allele was found to be associated with BMI compared to the CC genotype (P=0.017). Logistic regression analysis confirmed that the INSIG2 T-allele is associated with high BMI levels in controls, while low serum HDL-C in CAD patients. Based on our findings, it can be deduced that these INSIG2 and SCAP variants contribute to CAD risk.