Evaluation of Adenovirus-36 (Ad-36) antibody seropositivity and adipokine levels in obese children
Yazar
Sirekbasan, Serhat
Atalik, Keyser
Saribas, Suat
Ergin, Sevgi
Karakullukcu, Asiye
Imamova, Nergiz
Evliyaoglu, Olcay
Kocazeybek, Bekir
Altan, Eda
Cizmecigil, Utku
Dinc, Harika Oyku
Turan, Nuri
Yilmaz, Huseyin
Ozcabi, Bahar Taskm
Yuksel, Pelin
Taner, Zeynep
Cagatay, PENBE
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Adenovirus 36 (Ad-36) has recently been suggested as a possible contributor to the current obesity epidemic. The aim of this study was to investigate the prevalence of Ad-36 antibodies in obese children, as well as investigate the role of serum leptin and lipid levels in Ad-36-obesity. Seventy-one obese children and 62 non-obese children were included as the patient group (PG), including the healthy control group (HCG), respectively. Simultaneously, Ad-36 antibodies and adipokine levels were assessed with serum neutralization assays (SNA) and ELISA. Ad-36 antibody was detected in 9 patients (12.7%) and 1 patient (1.6%) in both the PG and HCG, respectively, while a significant difference was detected between groups (p < 0.05). Although serum LDL, total cholesterol, triglycerides and leptin levels were detected significantly higher, adiponectin level was detected paradoxically lower in the PG. However, a significant difference was not detected for lipids and leptin levels; adiponectin levels were found to be significantly lower in Ad-36 antibody-positive PG (p < 0.05).
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