dc.contributor.author | Celik, Tugba Zengin | |
dc.contributor.author | Saglam, Ebru | |
dc.contributor.author | Hacisalihoglu, Uguray Payam | |
dc.contributor.author | Doğan, Mehmet Ali | |
dc.contributor.author | Alinca, Suzan Bayer | |
dc.date.accessioned | 2021-03-05T19:27:24Z | |
dc.date.available | 2021-03-05T19:27:24Z | |
dc.identifier.citation | Saglam E., Alinca S. B. , Celik T. Z. , Hacisalihoglu U. P. , Doğan M. A. , "Evaluation of the effect of topical and systemic ozone application in periodontitis: an experimental study in rats.", Journal of applied oral science : revista FOB, cilt.28, 2019 | |
dc.identifier.issn | 1678-7757 | |
dc.identifier.other | vv_1032021 | |
dc.identifier.other | av_cf67f897-2f46-42c4-a046-ef9a6cedf444 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/137141 | |
dc.identifier.uri | https://doi.org/10.1590/1678-7757-2019-0140 | |
dc.description.abstract | Objective: The goal of the present study was to determine the effect of systemic and topical ozone application on alveolar bone loss (ABL) by evaluating the effect of Hypoxia-inducible factor -1 alpha (HIF-1-alpha) and receptor activator of NF-kappa B ligand (RANKL)-positive cells on histopathological and immunohistochemical changes in a rat periodontitis model. Methodology: Thirty male Wistar rats were divided into three groups: 1) Group C (control group); 2) Group SO (systemic ozone group) and 3) Group TO (topical ozone group). Experimental periodontitis was induced with a 3/0 silk suture placed at the mandibular left first molars of rats, and the suture was removed 14 days later. Ozone gas was injected intraperitoneally (0.7 mg/kg) in SO group. Topical ozone application protocol was performed using an ozone generator at 80% concentration (4th grade) 90- degree probe for the duration of 30 s. Both ozone applications were carried out for two weeks at intervals of two days. Histomorphometric and immunohistochemical analysis were performed. Results: ABL was significantly lower in Group SO compared to Group C (p: 0.0052). HIF-1 alpha- positive cells were significantly lower in Group TO than in Group C (p: 0.0043). RANKL-positive cells were significantly lower in Group SO and in Group TO compared to the control group (p: 0.0033, p: 0.0075, respectively). Conclusion: Both ozone applications decreased RANKL-positive cell counts, TO application decreased HIF-1-alpha positive cells counts, and SO application was found to be more effective in reducing ABL compared to control group. | |
dc.language.iso | eng | |
dc.subject | Diş Hekimliği | |
dc.subject | Sağlık Bilimleri | |
dc.subject | Tıp | |
dc.subject | Klinik Tıp (MED) | |
dc.subject | Klinik Tıp | |
dc.subject | DİŞ HEKİMLİĞİ, ORAL CERRAHİ VE TIP | |
dc.title | Evaluation of the effect of topical and systemic ozone application in periodontitis: an experimental study in rats. | |
dc.type | Makale | |
dc.relation.journal | Journal of applied oral science : revista FOB | |
dc.contributor.department | , , | |
dc.identifier.volume | 28 | |
dc.contributor.firstauthorID | 272843 | |