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dc.contributor.authorHermanns, W
dc.contributor.authorMuller, D
dc.contributor.authorMueller, J
dc.contributor.authorMinkus, Günter
dc.contributor.authorARUN, SEÇKİN SERDAR
dc.contributor.authorBreuer, W
dc.contributor.authorKirsch, M
dc.date.accessioned2021-03-05T19:50:02Z
dc.date.available2021-03-05T19:50:02Z
dc.date.issued1997
dc.identifier.citationMinkus G., Breuer W., ARUN S. S. , Kirsch M., Muller D., Mueller J., Hermanns W., "Ductuloendocrine cell proliferation in the pancreas of two young dogs with diabetes mellitus", VETERINARY PATHOLOGY, cilt.34, ss.164-167, 1997
dc.identifier.issn0300-9858
dc.identifier.othervv_1032021
dc.identifier.otherav_d119704a-0090-4e42-a5d6-be8a44d8d3c2
dc.identifier.urihttp://hdl.handle.net/20.500.12627/138223
dc.identifier.urihttps://doi.org/10.1177/030098589703400212
dc.identifier.urihttp://vet.sagepub.com/content/34/2/164.full.pdf+html
dc.description.abstractTwo cases of diabetes mellitus in juvenile does (a 3-4-month-old Golden Retriever and a 2-month-old Labrador Retriever) are described here in terms of their clinical, histologic, and immunohistologic findings. Only very few insulin-positive cells were demonstrated immunohistochemically in one dog. In the second dog, the alterations of the pancreas consisted of hydropic vacuolar degeneration of B cells in the islets of Langerhans. In both cases, hyperplasia of the vacuolated cells was prominent. These cells formed tubular structures and were immunohistochemically positive for cytokeratin and proliferating eel antigen (MIB-1). Furthermore, within these vacuolated areas, some cells were positive to varying degrees for insulin, glucagon, somatostatin, and pancreatic polypeptide. Apoptotic cells could be seen in the exocrine pancreas, in vacuolated areas, and occasionally in the islets of both dogs. We interpret these alterations as ductuloendocrine cell proliferation, probably as an idiopathic compensatory response.
dc.language.isoeng
dc.subjectBiyokimya
dc.subjectCerrahi Tıp Bilimleri
dc.subjectPatoloji
dc.subjectVeteriner Bilimleri
dc.subjectTarımsal Bilimler
dc.subjectYaşam Bilimleri
dc.subjectTemel Bilimler
dc.subjectTemel Tıp Bilimleri
dc.subjectSağlık Bilimleri
dc.subjectTıp
dc.subjectTarım ve Çevre Bilimleri (AGE)
dc.subjectBitki ve Hayvan Bilimleri
dc.subjectVETERİNERLİK BİLİMLERİ
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectBiyoloji ve Biyokimya
dc.subjectPATOLOJİ
dc.titleDuctuloendocrine cell proliferation in the pancreas of two young dogs with diabetes mellitus
dc.typeMakale
dc.relation.journalVETERINARY PATHOLOGY
dc.contributor.department, ,
dc.identifier.volume34
dc.identifier.issue2
dc.identifier.startpage164
dc.identifier.endpage167
dc.contributor.firstauthorID728312


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