Is the severity of Periodontitis Related to Gingival Crevicular Fluid and Serum High-Sensitivity C-Reactive Protein Concentrations?

Abstract

Background: Periodontitis is a chronic multifactorial inflammatory disease caused by microorganisms and characterized by progressive destruction of the tooth supporting tissues leading to tooth loss. Periodontal diseases are associated with an increase in CRP (C-reactive protein) levels. Release of the cytokines such as prostaglandin-E-2 (PGE(2)), and interleukin-1-beta (IL-1 beta) from the periodontal lesion, stimulate hepatocytes and circulating leukocytes to produce CRP. The purpose of this cross-sectional study was to evaluate serum levels of hs-CRP (high sensitive C-reactive protein) and gingival crevicular fluid (GCF) levels of hs-CRP, PGE2, and IL-1 beta in patients with varying degrees of periodontal disease.