SYNTHESIS, CHARACTERIZATION, AND BIOLOGICAL PROPERTIES OF NOVEL PIPERIDINOLYL-, PIPERIDINYL-, AND PIPERAZINYL-SUBSTITUTED NAPHTHOQUINONE COMPOUNDS AND THEIR REACTIONS WITH SOME THIOLS

Abstract

Nucleophillic substitution reactions of 2,3-dichloro-1,4-naphthoquinone (1) were studied using a variety of piperidinol, piperidine, and piperazine derivatives. The N-substituted compounds were treated with some thiols and N,S-substituted compounds were formed. The structures of the new products were characterized by spectroscopic methods (H-1 NMR, C-13 NMR, MS) and elemental analysis. The novel compounds were evaluated for their antibacterial and antifungal activity.