EFFECT OF URIDINE DIPHOSPHATE-GLUCURONOSYLTRANSFERASE POLYMORPHISMS ON THE PLASMA CONCENTRATIONS OF MYCOPHENOLIC ACID IN TURKISH RENAL TRANSPLANT PATIENTS

Date
2017
Author
Tefik, Tzevat
Demir, Erol
Turkmen, Aydin
Savran Oguz, Fatma
Senturk Ciftci, HAYRİYE
Savran Karadeniz, Meltem
Nane, Ismet
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Abstract
Objective: The pharmacokinetics of mycophenolic acid (MPA) differ among individuals. MPA is primarily metabolized by uridine diphosphate-glucuronosyltransferase (UGT), and UGT2B7 is an important UGT for the glucuronidation of MPA. This study aimed to examine the pharmacokinetics of MPA in Turkish renal transplant patients with UGT2B7 His268Tyr (802C>T) polymorphisms.
URI
http://hdl.handle.net/20.500.12627/140091
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